1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Fevipiprant

Fevipiprant (Synonyms: QAW039; NVP-QAW039)

Cat. No.: HY-16768 Purity: 99.63%
Handling Instructions

Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma.

For research use only. We do not sell to patients.

Fevipiprant Chemical Structure

Fevipiprant Chemical Structure

CAS No. : 872365-14-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 87 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 79 In-stock
Estimated Time of Arrival: December 31
10 mg USD 119 In-stock
Estimated Time of Arrival: December 31
25 mg USD 238 In-stock
Estimated Time of Arrival: December 31
50 mg USD 317 In-stock
Estimated Time of Arrival: December 31
100 mg USD 581 In-stock
Estimated Time of Arrival: December 31
200 mg USD 977 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fevipiprant

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma[1][2][3].

IC50 & Target[1]

CRTH2/DP2 Receptor

1.14 nM (Kd)

In Vitro

Fevipiprant (0-10 µM) inhibits the gene expression of IL-4, IL-3, IL-5, IL-8, CSF1, CSF2 in n in human Th2 cells induced by activated mast cell supernatants[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fevipiprant (10 mg/kg; in the drinking water) reduces CaCl2-induced AAA (abdominal aortic aneurysm) formation in mouse[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice[3]
Dosage: 10 mg/kg
Administration: In the drinking water
Result: Efficiently reduced CaCl2-induced AAA formation with diminished elastin degradation, aortic macrophage infiltration, MPO accumulation and MCP-1 expression.
Clinical Trial
Molecular Weight

426.41

Formula

C19H17F3N2O4S

CAS No.
SMILES

O=C(O)CC1=C(C)N(CC2=CC=C(S(=O)(C)=O)C=C2C(F)(F)F)C3=NC=CC=C31

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (75.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3452 mL 11.7258 mL 23.4516 mL
5 mM 0.4690 mL 2.3452 mL 4.6903 mL
10 mM 0.2345 mL 1.1726 mL 2.3452 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.63%

References
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Product Name:
Fevipiprant
Cat. No.:
HY-16768
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