2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Fevipiprant

Fevipiprant  (Synonyms: QAW039; NVP-QAW039)

Cat. No.: HY-16768 Purity: 99.51%
COA Handling Instructions

Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma.

For research use only. We do not sell to patients.

Fevipiprant Chemical Structure

Fevipiprant Chemical Structure

CAS No. : 872365-14-5

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Solid + Solvent
10 mM * 1 mL in DMSO
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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
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10 mg USD 90 In-stock
25 mg USD 180 In-stock
50 mg USD 280 In-stock
100 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

Fevipiprant Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fevipiprant

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma[1][2][3].

IC50 & Target[1]

DP2

1.14 nM (Kd)

In Vitro

Fevipiprant (0-10 µM) inhibits the gene expression of IL-4, IL-3, IL-5, IL-8, CSF1, CSF2 in n in human Th2 cells induced by activated mast cell supernatants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fevipiprant Related Antibodies
In Vivo

Fevipiprant (10 mg/kg; in the drinking water) reduces CaCl2-induced AAA (abdominal aortic aneurysm) formation in mouse[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice[3]
Dosage: 10 mg/kg
Administration: In the drinking water
Result: Efficiently reduced CaCl2-induced AAA formation with diminished elastin degradation, aortic macrophage infiltration, MPO accumulation and MCP-1 expression.
Clinical Trial
Molecular Weight

426.41

Appearance

Solid

Formula

C19H17F3N2O4S
CAS No.
SMILES

O=C(O)CC1=C(C)N(CC2=CC=C(S(=O)(C)=O)C=C2C(F)(F)F)C3=NC=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (75.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3452 mL 11.7258 mL 23.4516 mL
5 mM 0.4690 mL 2.3452 mL 4.6903 mL
10 mM 0.2345 mL 1.1726 mL 2.3452 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.51%

COA (259 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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Fevipiprant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fevipiprant872365-14-5QAW039 NVP-QAW039QAW 039QAW-039Prostaglandin ReceptorTh2 cellsbronchial asthmaabdominal aortic aneurysmIL-4orally activeInhibitorinhibitorinhibit

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