1. GPCR/G Protein
  2. Prostaglandin Receptor

MK-2894 

Cat. No.: HY-10413 Purity: 97.11%
Handling Instructions

MK-2894 is a highly potent and selective second generation EP4 antagonist.

For research use only. We do not sell to patients.

MK-2894 Chemical Structure

MK-2894 Chemical Structure

CAS No. : 1006036-87-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 224 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 204 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 343 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1296 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of MK-2894:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

MK-2894 is a highly potent and selective second generation EP4 antagonist. IC50 value: Target: EP4 MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1119 mL 10.5594 mL 21.1189 mL
5 mM 0.4224 mL 2.1119 mL 4.2238 mL
10 mM 0.2112 mL 1.0559 mL 2.1119 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

473.51

Formula

C₂₅H₂₂F₃NO₃S

CAS No.

1006036-87-8

SMILES

O=C(O)C1=CC=C(C2(NC(C3=C(C)SC(C)=C3CC4=CC=C(C(F)(F)F)C=C4)=O)CC2)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
MK-2894
Cat. No.:
HY-10413
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