1. GPCR/G Protein
  2. Prostaglandin Receptor

Setipiprant (Synonyms: ACT-129968; KYTH-105)

Cat. No.: HY-16635 Purity: 98.17%
Handling Instructions

Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.

For research use only. We do not sell to patients.

Setipiprant Chemical Structure

Setipiprant Chemical Structure

CAS No. : 866460-33-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 190 In-stock
Estimated Time of Arrival: December 31
100 mg USD 290 In-stock
Estimated Time of Arrival: December 31
200 mg USD 490 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

Description

Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2. IC50 value: 6.0 nM Target: PGD2 in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (89.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4850 mL 12.4248 mL 24.8497 mL
5 mM 0.4970 mL 2.4850 mL 4.9699 mL
10 mM 0.2485 mL 1.2425 mL 2.4850 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight

402.42

Formula

C₂₄H₁₉FN₂O₃

CAS No.

866460-33-5

SMILES

O=C(O)CN1C2=C(CN(C(C3=C4C=CC=CC4=CC=C3)=O)CC2)C5=C1C=CC(F)=C5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Setipiprant
Cat. No.:
HY-16635
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Setipiprant

Cat. No.: HY-16635