1. GPCR/G Protein
  2. Prostaglandin Receptor

Grapiprant (Synonyms: CJ-023423; RQ-00000007; AAT-007)

Cat. No.: HY-16781 Purity: 99.52%
Data Sheet SDS Handling Instructions

Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).

For research use only. We do not sell to patients.
Grapiprant Chemical Structure

Grapiprant Chemical Structure

CAS No. : 415903-37-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $264 In-stock
5 mg $240 In-stock
10 mg $420 In-stock
25 mg $840 In-stock
50 mg $1300 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Target: prostaglandin receptor in vitro: Grapiprant is a novel pharmacologically active ingredient, acts as a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). [1] in vivo: Grapiprant is currently under development for use in humans and dogs for the control of pain and inflammation associated with osteoarthritis. [1] Results suggested the safety of long-term oral administration of grapiprant to dogs. Efficacy of grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies. [2]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02538432 University of Maryland Prostate Cancer|Non-Small Cell Lung Cancer|Breast Cancer June 2017 Phase 2
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References
Molecular Weight

491.61

Formula

C₂₆H₂₉N₅O₃S

CAS No.

415903-37-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Grapiprant
Cat. No.:
HY-16781
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