1. GPCR/G Protein
  2. Prostaglandin Receptor

Grapiprant (Synonyms: CJ-023423; RQ-00000007; AAT-007)

Cat. No.: HY-16781 Purity: 99.68%
Handling Instructions

Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).

For research use only. We do not sell to patients.

Grapiprant Chemical Structure

Grapiprant Chemical Structure

CAS No. : 415903-37-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 317 In-stock
Estimated Time of Arrival: December 31
5 mg USD 288 In-stock
Estimated Time of Arrival: December 31
10 mg USD 504 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1008 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1560 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Target: prostaglandin receptor in vitro: Grapiprant is a novel pharmacologically active ingredient, acts as a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). [1] in vivo: Grapiprant is currently under development for use in humans and dogs for the control of pain and inflammation associated with osteoarthritis. [1] Results suggested the safety of long-term oral administration of grapiprant to dogs. Efficacy of grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies. [2]

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0341 mL 10.1707 mL 20.3413 mL
5 mM 0.4068 mL 2.0341 mL 4.0683 mL
10 mM 0.2034 mL 1.0171 mL 2.0341 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Grapiprant is formulated in PBS+30% DMSO[3].

References
Molecular Weight

491.61

Formula

C₂₆H₂₉N₅O₃S

CAS No.

415903-37-6

SMILES

O=S(C1=CC=C(C)C=C1)(NC(NCCC2=CC=C(N3C(CC)=NC4=C3C=C(C)N=C4C)C=C2)=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.68%

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Grapiprant
Cat. No.:
HY-16781
Quantity:

Grapiprant

Cat. No.: HY-16781