1. GPCR/G Protein
  2. Prostaglandin Receptor

Laropiprant (Synonyms: MK-0524)

Cat. No.: HY-50175 Purity: 99.66%
Data Sheet SDS Handling Instructions

Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM, and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).

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Laropiprant Chemical Structure

Laropiprant Chemical Structure

CAS No. : 571170-77-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $149 In-stock
5 mg $135 In-stock
10 mg $195 In-stock
50 mg $700 In-stock
100 mg $850 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM, and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).

IC50 & Target

Ki: 0.57 nM (DP1 receptor)

In Vitro

Laropiprant (1 µM) causes a significant inhibition of the aggregation but still counteractes the pronounced inhibition caused by PGD2 (30 nM) and BW245c (3 nM). Laropiprant blocks DP receptor-dependent increase in VASP phosphorylation, as well as inhibition of P-selectin expression, GPIIb/IIIa activation and in vitro thrombus formation. Laropiprant antagonizes the increased platelet aggregation by TP and EP3 receptor activation. Laropiprant (10 µM) and niacin inhibit in vitro thrombus formation[1].

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2941 mL 11.4705 mL 22.9410 mL
5 mM 0.4588 mL 2.2941 mL 4.5882 mL
10 mM 0.2294 mL 1.1471 mL 2.2941 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

435.9

Formula

C₂₁H₁₉ClFNO₄S

CAS No.

571170-77-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Laropiprant
Cat. No.:
HY-50175
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