1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Enzalutamide carboxylic acid

Enzalutamide carboxylic acid (Synonyms: MDV3100 carboxylic acid)

Cat. No.: HY-70002B
Handling Instructions

Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist.

For research use only. We do not sell to patients.

Enzalutamide carboxylic acid Chemical Structure

Enzalutamide carboxylic acid Chemical Structure

CAS No. : 1242137-15-0

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Description

Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist[1].

In Vitro

Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

451.39

Formula

C₂₀H₁₃F₄N₃O₃S

CAS No.

1242137-15-0

SMILES

O=C(O)C1=CC=C(N(C(N2C3=CC=C(C#N)C(C(F)(F)F)=C3)=S)C(C)(C)C2=O)C=C1F

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Enzalutamide carboxylic acidMDV3100 carboxylic acidDrug Metabolitemetaboliteandrogenreceptormetastaticcastration-resistantprostatecancerInhibitorinhibitorinhibit

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Enzalutamide carboxylic acid
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HY-70002B
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