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  3. N-desmethyl Enzalutamide

N-desmethyl Enzalutamide (Synonyms: N-desmethyl MDV 3100)

Cat. No.: HY-70002A Purity: 99.70%
Handling Instructions

N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.

For research use only. We do not sell to patients.

N-desmethyl Enzalutamide Chemical Structure

N-desmethyl Enzalutamide Chemical Structure

CAS No. : 1242137-16-1

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10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
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Other Forms of N-desmethyl Enzalutamide:

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Description

N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.

IC50 & Target

Androgen-receptor[1]

In Vivo

N-desmethyl Enzalutamide is an active metabolite that is thought to contribute to the clinical effects of Enzalutamide because it demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as Enzalutamide. The carboxylic acid metabolite is pharmacologically inactive and circulates at approximately 25 % lower plasma concentrations than Enzalutamide[1].

Molecular Weight

450.41

Formula

C₂₀H₁₄F₄N₄O₂S

CAS No.

1242137-16-1

SMILES

S=C(N1C2=CC(F)=C(C(N)=O)C=C2)N(C3=CC=C(C(C(F)(F)F)=C3)C#N)C(C(C)1C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 48 mg/mL (106.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2202 mL 11.1010 mL 22.2020 mL
5 mM 0.4440 mL 2.2202 mL 4.4404 mL
10 mM 0.2220 mL 1.1101 mL 2.2202 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.70%

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N-desmethyl Enzalutamide
Cat. No.:
HY-70002A
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