Remdesivir nucleoside monophosphate
Based on 3 publication(s) in Google Scholar
Remdesivir nucleoside monophosphate is a metabolite of Remdesivir (HY-104077).
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 1911578-74-9
- Formula: C12H14N5O7P
- Molecular Weight:371.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Remdesivir nucleoside monophosphate
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
Remdesivir is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1911578-74-9
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Appearance Solid
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Molecular Weight 371.24
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Formula C12H14N5O7P
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@](C#N)(C2=CC=C3C(N)=NC=NN32)O[C@@H]1COP(O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Nucleic Acids Res
COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. [Abstract]2021 Jan 8;49(D1):D1113-D1121. PMID: 33166390 -
J Med Chem
Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung. [Abstract]2024 May 9;67(9):7470-7486. PMID: 38690769 -
J Biol Chem
Activation of the SARS-CoV-2 NSP14 3'-5' exoribonuclease by NSP10 and response to antiviral inhibitors. [Abstract]2022 Jan;298(1):101518. PMID: 34942146
Solvent & Solubility
DMSO : 25 mg/mL (67.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18. [Content Brief]
[2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. [Content Brief]
[3]. Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 22;65(18):12044-12054. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6937 mL | 13.4684 mL | 26.9368 mL | 67.3419 mL |
| 5 mM | 0.5387 mL | 2.6937 mL | 5.3874 mL | 13.4684 mL | |
| 10 mM | 0.2694 mL | 1.3468 mL | 2.6937 mL | 6.7342 mL | |
| 15 mM | 0.1796 mL | 0.8979 mL | 1.7958 mL | 4.4895 mL | |
| 20 mM | 0.1347 mL | 0.6734 mL | 1.3468 mL | 3.3671 mL | |
| 25 mM | 0.1077 mL | 0.5387 mL | 1.0775 mL | 2.6937 mL | |
| 30 mM | 0.0898 mL | 0.4489 mL | 0.8979 mL | 2.2447 mL | |
| 40 mM | 0.0673 mL | 0.3367 mL | 0.6734 mL | 1.6835 mL | |
| 50 mM | 0.0539 mL | 0.2694 mL | 0.5387 mL | 1.3468 mL | |
| 60 mM | 0.0449 mL | 0.2245 mL | 0.4489 mL | 1.1224 mL |
Remdesivir nucleoside monophosphate Related Classifications
HY-44358 Related Classifications
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