1. GPCR/G Protein
  2. Leukotriene Receptor
  3. Amelubant

Amelubant (Synonyms: BIIL 284)

Cat. No.: HY-19304
Handling Instructions

Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Amelubant Chemical Structure

Amelubant Chemical Structure

CAS No. : 346735-24-8

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Description

Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1].

IC50 & Target[1]

LTB4

221 nM (Ki, in vital human granulocytes)

LTB4

230 nM (Ki, in cell membranes)

In Vitro

Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively[1].

Clinical Trial
Molecular Weight

538.63

Formula

C₃₃H₃₄N₂O₅

CAS No.

346735-24-8

SMILES

CC(C1=CC=C(OCC2=CC(COC3=CC=C(C(NC(OCC)=O)=N)C=C3)=CC=C2)C=C1)(C4=CC=C(O)C=C4)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Amelubant
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