Amelubant (Synonyms: BIIL 284)

Cat. No.: HY-19304 Purity: 99.11%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Amelubant (BIIL 284) is a potent, oral and long acting LTB₄ receptor antagonist, negligibly binds to LTB₄ receptor, with K_is of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a proagent of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Amelubant Chemical Structure

CAS No. : 346735-24-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 569	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 569	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3600	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

IC₅₀ & Target

Ki: 221 nM (LTB₄ receptor, in vital human granulocytes), 230 nM (LTB₄ receptor, in cell membranes)^[1]

In Vitro

Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB₄ receptor antagonists, with K_is of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

538.63

Formula

C₃₃H₃₄N₂O₅

CAS No.

346735-24-8

Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(OCC2=CC(COC3=CC=C(C(NC(OCC)=O)=N)C=C3)=CC=C2)C=C1)(C4=CC=C(O)C=C4)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (185.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8566 mL	9.2828 mL	18.5656 mL
5 mM	0.3713 mL	1.8566 mL	3.7131 mL
10 mM	0.1857 mL	0.9283 mL	1.8566 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.11%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (242 KB) HNMR (271 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8566 mL	9.2828 mL	18.5656 mL	46.4141 mL
	5 mM	0.3713 mL	1.8566 mL	3.7131 mL	9.2828 mL
	10 mM	0.1857 mL	0.9283 mL	1.8566 mL	4.6414 mL
	15 mM	0.1238 mL	0.6189 mL	1.2377 mL	3.0943 mL
	20 mM	0.0928 mL	0.4641 mL	0.9283 mL	2.3207 mL
	25 mM	0.0743 mL	0.3713 mL	0.7426 mL	1.8566 mL
	30 mM	0.0619 mL	0.3094 mL	0.6189 mL	1.5471 mL
	40 mM	0.0464 mL	0.2321 mL	0.4641 mL	1.1604 mL
	50 mM	0.0371 mL	0.1857 mL	0.3713 mL	0.9283 mL
	60 mM	0.0309 mL	0.1547 mL	0.3094 mL	0.7736 mL
	80 mM	0.0232 mL	0.1160 mL	0.2321 mL	0.5802 mL
	100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.4641 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amelubant346735-24-8BIIL 284BIIL284BIIL-284Inhibitorinhibitorinhibit

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