2. Apoptosis PI3K/Akt/mTOR Stem Cell/Wnt
  3. Apoptosis GSK-3 c-Myc β-catenin
  4. Secalonic acid D

Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis.

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Secalonic acid D

Secalonic acid D Chemical Structure

CAS No. : 35287-69-5

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Based on 1 publication(s) in Google Scholar

Secalonic acid D Related Antibodies

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Description

Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
2.1 μM
Compound: 7
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 26506221]
HCT-116 IC50
0.9 μM
Compound: 7
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 26506221]
HL-60 IC50
1 μM
Compound: 7
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 26506221]
K562 IC50
2 μM
Compound: 7
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 26506221]
MGC-803 IC50
1.5 μM
Compound: 7
Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay
Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay
[PMID: 26506221]
In Vitro

Secalonic acid D (0.1-1 μM; 72 h) inhibits cell proliferation in a concentration-dependent manner in both HL60 and K562, with IC50s of 0.38 μM and 0.43 μM, respectively[1].
Secalonic acid D (0.3 μM; 12 h, 24 h) causes cell cycle arrest of G1 phase and (1.2 μM; 0-72 h) induces apoptosis in HL60 and K562 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Secalonic acid D Related Antibodies

Apoptosis Analysis[1]

Cell Line: HL60 and K562 cells
Concentration: 1.2 μM
Incubation Time: 0, 24, 48 and 72 h
Result: Induced cell apoptosis via arresting cell cycle at G1 phase. As well as, down-regulated the expression level of c-Myc.

Western Blot Analysis[1]

Cell Line: HL60 and K562 cells
Concentration: 1.2 μM
Incubation Time: 0, 24, 48 and 72 h
Result: Dose-dependently decreases the level of Caspase-1.
Molecular Weight

638.57

Formula

C32H30O14
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC([C@]12C(C(C3=C(O)C(C4=CC=C(O[C@@]5(C(C6=O)=C(C[C@@H]([C@H]5O)C)O)C(OC)=O)C6=C4O)=CC=C3O1)=O)=C(C[C@@H]([C@H]2O)C)O)=O
Structure Classification
Initial Source

aspergillus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (156.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5660 mL 7.8300 mL 15.6600 mL
5 mM 0.3132 mL 1.5660 mL 3.1320 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5660 mL 7.8300 mL 15.6600 mL 39.1500 mL
5 mM 0.3132 mL 1.5660 mL 3.1320 mL 7.8300 mL
10 mM 0.1566 mL 0.7830 mL 1.5660 mL 3.9150 mL
15 mM 0.1044 mL 0.5220 mL 1.0440 mL 2.6100 mL
20 mM 0.0783 mL 0.3915 mL 0.7830 mL 1.9575 mL
25 mM 0.0626 mL 0.3132 mL 0.6264 mL 1.5660 mL
30 mM 0.0522 mL 0.2610 mL 0.5220 mL 1.3050 mL
40 mM 0.0391 mL 0.1957 mL 0.3915 mL 0.9787 mL
50 mM 0.0313 mL 0.1566 mL 0.3132 mL 0.7830 mL
60 mM 0.0261 mL 0.1305 mL 0.2610 mL 0.6525 mL
80 mM 0.0196 mL 0.0979 mL 0.1957 mL 0.4894 mL
100 mM 0.0157 mL 0.0783 mL 0.1566 mL 0.3915 mL
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Secalonic acid D Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Secalonic acid D35287-69-5ApoptosisGSK-3c-Mycβ-cateninGlycogen synthase kinase-3Glycogen synthase kinase 3MycBeta cateninapoptosiscell cycleGSK-3β/β-catenin/c-MycHL60 and K562 cellInhibitorinhibitorinhibit

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