Secalonic acid D 

Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis^[1][2].

Secalonic acid D (0.1-1 μM; 72 h) inhibits cell proliferation in a concentration-dependent manner in both HL60 and K562, with IC₅₀s of 0.38 μM and 0.43 μM, respectively^[1].
Secalonic acid D (0.3 μM; 12 h, 24 h) causes cell cycle arrest of G1 phase and (1.2 μM; 0-72 h) induces apoptosis in HL60 and K562 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

638.57

C₃₂H₃₀O₁₄

35287-69-5

COC([C@]12C(C(C3=C(O)C(C4=CC=C(O[C@@]5(C(C6=O)=C(C[C@@H]([C@H]5O)C)O)C(OC)=O)C6=C4O)=CC=C3O1)=O)=C(C[C@@H]([C@H]2O)C)O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Andersen R, et al. Secalonic acids D and F are toxic metabolites of Aspergillus aculeatus. J Org Chem. 1977 Jan 21;42(2):352-3.  [Content Brief]

  [2]. Zhang JY, et al. Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G(1) with involvement of GSK-3beta/beta-catenin/c-Myc pathway. Cell Cycle. 2009 Aug;8(15):2444-50.  [Content Brief]