35287-69-5
Chemical Structure
Secalonic acid D
- CAS No.: 35287-69-5
- Formula:C32H30O14
- Molecular Weight:638.57
IUPAC Name: dimethyl (5R,5'R,6S,6'S,10aR,10'aR)-1,1',5,5',8,8'-hexahydroxy-6,6'-dimethyl-9,9'-dioxo-5,5',6,6',7,7',9,9'-octahydro-10aH,10'aH-[2,2'-bixanthene]-10a,10'a-dicarboxylate
InChIKey: DRYDKQOPVBDZMQ-OCHURCMPSA-N
SMILES: COC([C@]12C(C(C3=C(O)C(C4=CC=C(O[C@@]5(C(C6=O)=C(C[C@@H]([C@H]5O)C)O)C(OC)=O)C6=C4O)=CC=C3O1)=O)=C(C[C@@H]([C@H]2O)C)O)=O
Biological Activity: Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Secalonic acid D | 99.63% | Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis. | ||||||||||||||||||||
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- [1]. Andersen R, et al. Secalonic acids D and F are toxic metabolites of Aspergillus aculeatus. J Org Chem. 1977 Jan 21;42(2):352-3. [Content Brief]
- [2]. Zhang JY, et al. Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G(1) with involvement of GSK-3beta/beta-catenin/c-Myc pathway. Cell Cycle. 2009 Aug;8(15):2444-50. [Content Brief]
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