Asukamycin 

Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines^[1][2].

Asukamycin (1-50 μM; 24 h) in a concentration-dependent manner reduces viability of five different human cell lines with IC₅₀ of 1-5 μM^[1].
Asukamycin (50 μM; 24 and 72 h; THP-1 cells) causes a significant increase in intracellular caspase 8 and caspase 3 activity^[1].
Asukamycin (0-100 mcg/mL; bacteria, 18 h; fungus, 72 h) has antimicrobial activity. Asukamycin inhibits the growth of Gram-positive bacteria within a concentration range of 0.78-12.5 mcg/mL and inhibits the growth of Trichophyton mentagrophytes at a concentration of 25 mcg/ mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Asukamycin (0-450 mg/kg; i.p.; mice) has low toxicity in vivo. Asukamycin has acute toxicity with an LD₅₀ value of 48.5 mg/kg by intraperitoneal injection^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

546.61

C₃₁H₃₄N₂O₇

61116-33-4

Solid

Light yellow to yellow

O=C1[C@@H]2[C@H]([C@@](O)(C=C1NC(/C=C/C=C/C=C/C3CCCCC3)=O)/C=C/C=C/C=C/C(NC4=C(CCC4=O)O)=O)O2

Room temperature in continental US; may vary elsewhere.

• [1]. Shipley PR, et, al. Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Int J Mol Med. 2009 Nov;24(5):711-5.  [Content Brief]

  [2]. Omura S, et, al. A new antibiotic,, asukamycin, produced by Streptomyces. J Antibiot (Tokyo). 1976 Sep;29(9):876-81.  [Content Brief]