2. Membrane Transporter/Ion Channel Others
  3. OAT Fluorescent Dye P-glycoprotein
  4. Indican

Indican  (Synonyms: Indoxyl-β-D-glucoside)

Cat. No.: HY-122009 Purity: 99.78%
COA
SDS
Handling Instructions Technical Support

Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4.

For research use only. We do not sell to patients.

Indican

Indican Chemical Structure

CAS No. : 487-60-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
50 mg In-stock
100 mg In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].

In Vivo

Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Spraguee Dawley rats weighing 330-400 g[1]
Dosage: 20, 40 mg/kg
Administration: Orally
Result: Increased the systemic exposure and multidrug resistance-associated protein (MRP) of Methotrexate (MTX; 5.0 mg/kg).
Molecular Weight

295.29

Formula

C14H17NO6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC2=CNC3=C2C=CC=C3)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (338.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 83.33 mg/mL (282.20 mM; Need ultrasonic)

H2O : 20 mg/mL (67.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3865 mL 16.9325 mL 33.8650 mL
5 mM 0.6773 mL 3.3865 mL 6.7730 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

SDS (393 KB)

COA (254 KB) HNMR (134 KB) RP-HPLC (230 KB) LCMS (323 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / Methanol / DMSO 1 mM 3.3865 mL 16.9325 mL 33.8650 mL 84.6625 mL
5 mM 0.6773 mL 3.3865 mL 6.7730 mL 16.9325 mL
10 mM 0.3387 mL 1.6933 mL 3.3865 mL 8.4663 mL
15 mM 0.2258 mL 1.1288 mL 2.2577 mL 5.6442 mL
20 mM 0.1693 mL 0.8466 mL 1.6933 mL 4.2331 mL
25 mM 0.1355 mL 0.6773 mL 1.3546 mL 3.3865 mL
30 mM 0.1129 mL 0.5644 mL 1.1288 mL 2.8221 mL
40 mM 0.0847 mL 0.4233 mL 0.8466 mL 2.1166 mL
50 mM 0.0677 mL 0.3387 mL 0.6773 mL 1.6933 mL
60 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4110 mL
Methanol / DMSO 80 mM 0.0423 mL 0.2117 mL 0.4233 mL 1.0583 mL
100 mM 0.0339 mL 0.1693 mL 0.3387 mL 0.8466 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Indican Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indican487-60-5Indoxyl-β-D-glucosideOATFluorescent DyeP-glycoproteinOrganic anion transporterP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243glycosideindoxyldyesindigoindirubinsulfateISuremictoxinorganicaniontransporterOAT1OAT3MRP4Inhibitorinhibitorinhibit

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