487-60-5
487-60-5
Chemical Structure
Indican
Synonym(s): Indoxyl-β-D-glucoside
- CAS No.: 487-60-5
- Formula:C14H17NO6
- Molecular Weight:295.29
IUPAC Name: (2S,3R,4S,5S,6R)-2-((1H-indol-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: XVARCVCWNFACQC-RKQHYHRCSA-N
SMILES: O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC2=CNC3=C2C=CC=C3)CO
Biological Activity: Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Indican | 99.78% | Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-Indolyl-β-D-glucuronide | 3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in plasma act as a new indicator of renal failure. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
5-Bromo-3-indolyl β-D-galactopyranoside | 99.89% | 5-Bromo-3-indolyl β-D-galactopyranoside (Bluo-Gal) is a chromogenic substrate for β-galactosidase. 5-Bromo-3-indolyl β-D-galactopyranoside is hydrolyzed by the enzyme to generate a 5-bromoindole intermediate, which is further oxidized to form an insoluble blue precipitate. 5-Bromo-3-indolyl β-D-galactopyranoside can specifically recognize bacterial β-galactosidases (such as the product of the Escherichia coli lacZ gene) and reacts at pH 7.4, making it suitable for light and electron microscopic observations. 5-Bromo-3-indolyl β-D-galactopyranoside can be used in histochemical detection of reporter gene expression in transgenic organisms, such as the localization analysis of β-galactosidase activity in mouse embryos or muscle tissues. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
6-Chloro-3-indolyl α-D-galactopyranoside | 6-Chloro-3-indolyl α-D-galactopyranoside can be used in glycobiology research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
6-Bromo-3-indolyl α-D-glucopyranoside | 6-Bromo-3-indolyl α-D-glucopyranoside is a halogenated 3-indolyl-α-D-glucopyranoside derivative. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Indoxyl β-D-galactopyranoside | Indoxyl β-D-galactopyranoside is a biochemical reagent. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Rose-β-D-Gal | 99.71% | Rose-β-D-Gal is a chromogenic substrate, is also a β-galactosidase substrate. Rose-β-D-Gal creates a pink/magenta color after the reaction and has been used for detection of β-gal activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Purple-β-D-Gal | Purple-β-D-Gal is a chromogenic β-galactosidase substrate. Intracellular enzymatic hydrolysis of Purple-β-D-Gal generates free indoxyl molecules, which undergo in situ oxidation and subsequent dimerization to produce chromogenic, water-insoluble, indigo precipitates. Purple-β-D-Gal can be used for the detection of β-galactosidase activity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
6-Fluoro-3-indolyl-β-D-galactopyranoside | 6-Fluoro-3-indolyl-β-D-galactopyranoside is a chromogenic enzyme substrate commonly used in microbiology to detect the expression of β-galactosidase in bacterial colonies. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
6-Chloro-1H-indol-3-yl β-D-glucopyranoside | 6-Chloro-1H-indol-3-yl β-D-glucopyranoside can be used to detect chromogenic medium for studying yeast with β-glucosidase activity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
6-Chloro-3-indoxyl-α-D-mannopyranoside | 6-Chloro-3-indoxyl-α-D-mannopyranoside is a chromogenic substrate for α-mannosidase resulting in a salmon colored precipitate upon cleavage. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140. [Content Brief]
- [2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4. [Content Brief]
