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indirubin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) CDK (6) Ferroptosis (1) FLT3 (1) Fluorescent Dye (1) GSK-3 (6) Isotope-Labeled Compounds (2) JNK (1) Lipoxygenase (1)
By Research Areas:	Cancer (8) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0117

*Indirubin* 5+ Cited Publications Couroupitine B; Indigo red; Indigopurpurin	Apoptosis	Cancer
Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-139254

Indirubin-3′-oxime IDR3O; I3O	CDK GSK-3 JNK	Neurological Disease
Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC₅₀s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes .

HY-19807

Indirubin-3'-monoxime 3 Publications Verification indirubin-3'-oxime	GSK-3 CDK Lipoxygenase	Cancer
Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC₅₀s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC₅₀s of 100 and 180 nM.

HY-111932

Indirubin-5-sulfonate	CDK GSK-3	Cancer
Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC₅₀ values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively . Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β .

HY-111931

Indirubin-3'-monoxime-5-sulphonic acid	CDK GSK-3	Cancer
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC₅₀s of 5 nM, 7 nM, and 80 nM, respectively .

HY-18785

Indirubin Derivative E804

Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC₅₀ of 0.65 μM for IGF1R.
HY-N0117AS

(Z)-Indirubin-d4

Apoptosis Isotope-Labeled Compounds Others

(Z)-Indirubin-d₄ is the deuterium labeled (Z)-Indirubin[1].
HY-N0117AS1

(Z)-Indirubin-d8

Isotope-Labeled Compounds Others

(Z)-Indirubin-d₈ is the deuterium labeled (Z)-Indirubin[1].

Indirubin Derivative E804
Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC₅₀ of 0.65 μM for IGF1R.

*(Z)-Indirubin-d4*	Apoptosis Isotope-Labeled Compounds	Others
(Z)-Indirubin-d₄ is the deuterium labeled (Z)-Indirubin[1].

*(Z)-Indirubin-d8*	Isotope-Labeled Compounds	Others
(Z)-Indirubin-d₈ is the deuterium labeled (Z)-Indirubin[1].

HY-111930

*5-Iodo-indirubin-3'-monoxime*	GSK-3 CDK	Cancer
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC₅₀s of 9, 20 and 25 nM, respectively .

HY-13680

Meisoindigo Dian III; N-Methylisoindigotin; Natura-α	Apoptosis	Cancer
Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity .

HY-122009

Indican Indoxyl-β-D-glucoside	Fluorescent Dye	Others
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

HY-156286

GPX4-IN-7	Ferroptosis	Cancer
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC₅₀ value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis .

HY-103464

5'-Fluoroindirubinoxime

5'-FIO
FLT3 Cancer

5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC₅₀ of 15 nM .

5'-Fluoroindirubinoxime 5'-FIO	FLT3	Cancer
5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC₅₀ of 15 nM .

HY-121035

7BIO 7-Bromoindirubin-3-Oxime	CDK GSK-3	Neurological Disease
7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0117

*Indirubin* 5+ Cited Publications Couroupitine B; Indigo red; Indigopurpurin	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-13680

Meisoindigo Dian III; N-Methylisoindigotin; Natura-α	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity .

HY-122009

Indican Indoxyl-β-D-glucoside	Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids Indigofera	Fluorescent Dye
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

Cat. No.	Product Name	Chemical Structure

HY-N0117AS

(Z)-Indirubin-d4

(Z)-Indirubin-d₄ is the deuterium labeled (Z)-Indirubin[1].
HY-N0117AS1

(Z)-Indirubin-d8

(Z)-Indirubin-d₈ is the deuterium labeled (Z)-Indirubin[1].

*(Z)-Indirubin-d4*
(Z)-Indirubin-d₄ is the deuterium labeled (Z)-Indirubin[1].

*(Z)-Indirubin-d8*
(Z)-Indirubin-d₈ is the deuterium labeled (Z)-Indirubin[1].

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indirubin

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products