1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    PI3K/Akt/mTOR
  2. CDK
    GSK-3
  3. Indirubin-5-sulfonate

Indirubin-5-sulfonate 

Cat. No.: HY-111932
Handling Instructions

Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β.

For research use only. We do not sell to patients.

Indirubin-5-sulfonate Chemical Structure

Indirubin-5-sulfonate Chemical Structure

CAS No. : 244021-67-8

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Description

Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].

IC50 & Target[1]

Cdk1/cyclin B

55 nM (IC50)

cdk2/cyclin A

35 nM (IC50)

CDK2/cyclinE

150 nM (IC50)

Cdk4/cyclin D1

300 nM (IC50)

CDK5/p35

65 nM (IC50)

GSK-3β

 

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

342.33

Formula

C₁₆H₁₀N₂O₅S

CAS No.

244021-67-8

SMILES

O=S(C1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C/3=O)=O)C=C1)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Indirubin-5-sulfonate
Cat. No.:
HY-111932
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Indirubin-5-sulfonate

Cat. No.: HY-111932