Indirubin-5-sulfonate
Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β.
For research use only. We do not sell to patients.
- CAS No.: 244021-67-8
- Formula: C16H10N2O5S
- Molecular Weight:342.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cdk1/cyclin B 55 nM (IC50) |
cdk2/cyclin A 35 nM (IC50) |
CDK2/cyclinE 150 nM (IC50) |
Cdk4/cyclin D1 300 nM (IC50) |
CDK5/p35 65 nM (IC50) |
GSK-3β |
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Cell Line
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Type | Value | Description | References |
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| Oocyte | IC50 |
0.055 μM
Compound: 19
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Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
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[PMID: 34161865] |
Chemical Information
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CAS No. 244021-67-8
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Molecular Weight 342.33
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Formula C16H10N2O5S
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SMILES
O=S(C1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C/3=O)=O)C=C1)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [Content Brief]
[2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indirubin-5-sulfonate Related Classifications
HY-111932 Related Classifications
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