244021-67-8
244021-67-8
Chemical Structure
Indirubin-5-sulfonate
- CAS No.: 244021-67-8
- Formula:C16H10N2O5S
- Molecular Weight:342.33
IUPAC Name: (E)-2',3-dioxo-[2,3'-biindolinylidene]-5'-sulfonic acid
InChIKey: IHBOEHLUIBMBMY-BUHFOSPRSA-N
SMILES: O=S(C1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C/3=O)=O)C=C1)(O)=O
Biological Activity: Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].
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Indirubin-5-sulfonate | Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. | |||||||||||||||||||||
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References
- [1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [Content Brief]
- [2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. [Content Brief]
