1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3

Indirubin-3'-monoxime (Synonyms: Indirubin-3'-oxime)

Cat. No.: HY-19807 Purity: 99.70%
Data Sheet SDS Handling Instructions

Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM).

For research use only. We do not sell to patients.
Indirubin-3'-monoxime Chemical Structure

Indirubin-3'-monoxime Chemical Structure

CAS No. : 160807-49-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $110 In-stock
50 mg $440 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Indirubin-3'-monoxime:

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Description

Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM). IC50 value: 22 nM [1] Target: GSK-3β in vitro: Indirubin-3′-monoxime acts as a competitive inhibitor of ATP binding. The apparent Ki was 0.85 μM. [1] In cell-based and cell-free assays, Indirubin-3'-monoxime selectively inhibits 5-lipoxygenase (5-LO), the key enzyme in LT biosynthesis, with an IC50 in the low micromolar range. Indirubin-3'-monoxime causes a concentration-dependent inhibition of all analysed products formed via the 5-LO pathway independent of the stimulus with IC50 values of 4.1 ± 1.1 and 4.3 ± 1.1 μM. [2] in vivo: Indirubin-3′-monoxime also inhibits the phosphorylation of DARPP-32 by CDK5 on Thr-75, thereby mimicking one of the effects of dopamine in the striatum.[1] Indirubin-3'-monoxime is a potent inhibitor of vascular smooth muscle cell (VSMC) proliferation (IC50 2 μM) and successfully blocks neointima formation in a murine femoral cuff model. [2] Indirubin-3′-monoxime is a GSK3β inhibitor, attenuates the HFD induced cognitive impairment in mice.Indirubin-3′-monoxime augment the level of brain insulin and BDNF in high fat diet fed mice. [3]

References
M.Wt

277.28

Formula

C₁₆H₁₁N₃O₂

CAS No.

160807-49-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 37 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Indirubin-3'-monoxime
Cat. No.:
HY-19807
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