1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    PI3K/Akt/mTOR
  2. CDK
    GSK-3

Kenpaullone (Synonyms: 9-Bromopaullone; NSC-664704)

Cat. No.: HY-12302 Purity: 98.09%
Data Sheet SDS Handling Instructions

Kenpaullone is an ATP-competitive inhibitor of several CDKs as well as GSK-3β, with an IC50 value of 0.23 μM for GSK-3β and 0.4, 0.68, 0.85, and 0.47 μM for CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, and lymphocyte kinase., respectively.

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Kenpaullone Chemical Structure

Kenpaullone Chemical Structure

CAS No. : 142273-20-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $90 In-stock
50 mg $380 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Kenpaullone is an ATP-competitive inhibitor of several CDKs as well as GSK-3β, with an IC50 value of 0.23 μM for GSK-3β and 0.4, 0.68, 0.85, and 0.47 μM for CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, and lymphocyte kinase., respectively. IC50 value: 0.23 μM (GSK-3β), 0.4 μM (CDK1/cyclin B), 0.68 μM (CDK2/cyclin A), 0.85μM (CDK5/p25), and 0.47 μM ( lymphocyte kinase) Target: CDK, GSK-3 in vitro: Kenpaullone is useful in the study of cell cycle regulators. Kenpaullone is an inhibitor of cyclin E, ERK 2 and p35. Kenpaullone is able to replace Klf4 in the reprogramming of primary and secondary fibroblasts and NPCs.

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.0564 mL 15.2821 mL 30.5642 mL
5 mM 0.6113 mL 3.0564 mL 6.1128 mL
10 mM 0.3056 mL 1.5282 mL 3.0564 mL
References
Molecular Weight

327.18

Formula

C₁₆H₁₁BrN₂O

CAS No.

142273-20-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 35 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Kenpaullone
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HY-12302
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