GPX4-IN-7
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC50 value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis.
For research use only. We do not sell to patients.
- Formula: C25H23ClN4O4
- Molecular Weight:478.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.49 μM (HCT-116 cells)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.49 μM
Compound: 31
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 48 hrs by CCK8 assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 48 hrs by CCK8 assay
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[PMID: 37801824] |
Chemical Information
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Molecular Weight 478.93
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Formula C25H23ClN4O4
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SMILES
O=C(NCC1CCN(CC1)C(CCl)=O)C(C=C2C/3=O)=CC=C2NC3=C4C(C=CC=C5)=C5NC\4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPX4-IN-7 Related Classifications
HY-156286 Related Classifications
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