1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Cell Cycle/DNA Damage
  2. GSK-3
    CDK
  3. 5-Iodo-indirubin-3'-monoxime

5-Iodo-indirubin-3'-monoxime 

Cat. No.: HY-111930
Handling Instructions

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.

For research use only. We do not sell to patients.

5-Iodo-indirubin-3'-monoxime Chemical Structure

5-Iodo-indirubin-3'-monoxime Chemical Structure

CAS No. : 331467-03-9

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Description

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

IC50 & Target[1]

GSK-3β

9 nM (IC50)

Cdk5/p25

20 nM (IC50)

Cdk1/cyclin B

25 nM (IC50)

Molecular Weight

403.17

Formula

C₁₆H₁₀IN₃O₂

CAS No.

331467-03-9

SMILES

O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
5-Iodo-indirubin-3'-monoxime
Cat. No.:
HY-111930
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