1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Cell Cycle/DNA Damage
  2. GSK-3
    CDK
  3. 5-Iodo-indirubin-3'-monoxime

5-Iodo-indirubin-3'-monoxime 

Cat. No.: HY-111930 Purity: 99.50%
Handling Instructions

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.

For research use only. We do not sell to patients.

5-Iodo-indirubin-3'-monoxime Chemical Structure

5-Iodo-indirubin-3'-monoxime Chemical Structure

CAS No. : 331467-03-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 310 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

IC50 & Target[1]

GSK-3β

9 nM (IC50)

Cdk5/p25

20 nM (IC50)

Cdk1/cyclin B

25 nM (IC50)

Molecular Weight

403.17

Formula

C₁₆H₁₀IN₃O₂

CAS No.

331467-03-9

SMILES

O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 67.5 mg/mL (167.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4803 mL 12.4017 mL 24.8034 mL
5 mM 0.4961 mL 2.4803 mL 4.9607 mL
10 mM 0.2480 mL 1.2402 mL 2.4803 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (5.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.50%

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Keywords:

5-Iodo-indirubin-3'-monoximeGSK-3CDKGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
5-Iodo-indirubin-3'-monoxime
Cat. No.:
HY-111930
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