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Cat. No.: HY-111930R

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5-Iodo-indirubin-3'-monoxime (Standard)

5-Iodo-indirubin-3'-monoxime (Standard) is the analytical standard of 5-Iodo-indirubin-3'-monoxime (HY-111930). This product is intended for research and analytical applications. 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the K_inase, with IC₅₀s of 9, 20 and 25 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 331467-03-9
Formula: C₁₆H₁₀IN₃O₂
Molecular Weight:403.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

5-Iodo-indirubin-3'-monoxime (Standard) Chemical Structure

CAS No.: 331467-03-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 331467-03-9
Molecular Weight 403.17
Formula C₁₆H₁₀IN₃O₂
SMILES

O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-Iodo-indirubin-3'-monoxime (Standard)

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5-Iodo-indirubin-3'-monoxime (Standard)

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5-Iodo-indirubin-3'-monoxime (Standard) Related Classifications

HY-111930R Related Classifications

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