1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    PI3K/Akt/mTOR
    MAPK/ERK Pathway
  2. CDK
    GSK-3
    JNK
  3. Indirubin-3′-oxime

Indirubin-3′-oxime (Synonyms: IDR3O; I3O)

Cat. No.: HY-139254
Handling Instructions

Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes.

For research use only. We do not sell to patients.

Indirubin-3′-oxime Chemical Structure

Indirubin-3′-oxime Chemical Structure

CAS No. : 667463-82-3

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Description

Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[1][2][3].

IC50 & Target[1][2][3]

JNK1

0.8 μM (IC50)

JNK2

1.4 μM (IC50)

JNK3

1 μM (IC50)

GSK-3β

 

CDK

 

In Vitro

In cerebellar granule neurons (CGNs), Indirubin-3′-oxime blocks c-Jun phosphorylation induced by potassium withdrawal and prevented CGNs from apoptosis in a dose dependent manner[1].
Indirubin-3′-oxime (IDR3O) (PC12 cells; 10 μM) significantly prevent 6OHDA-induced decrease of nuclear localized MEF2D expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Indirubin-3′-oxime (0.05 or 0.5 mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Three-week-old C57BL/6 mice[3]
Dosage: 0.05 or 0.5 mg/kg
Administration: I.p.; daily for 2 or 10 weeks
Result: The tibial length of mice increased in a dose-dependent manner.
Molecular Weight

277.28

Formula

C₁₆H₁₁N₃O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Indirubin-3′-oxime
Cat. No.:
HY-139254
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