1. Protein Tyrosine Kinase/RTK
  2. IGF-1R

Indirubin Derivative E804 

Cat. No.: HY-18785
Handling Instructions

E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.

For research use only. We do not sell to patients.

Indirubin Derivative E804 Chemical Structure

Indirubin Derivative E804 Chemical Structure

CAS No. : 854171-35-0

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.

IC50 & Target

IC50: 0.65 μM (IGF1R)[1].

In Vitro

Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7369 mL 13.6844 mL 27.3688 mL
5 mM 0.5474 mL 2.7369 mL 5.4738 mL
10 mM 0.2737 mL 1.3684 mL 2.7369 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

365.38

Formula

C₂₀H₁₉N₃O₄

CAS No.

854171-35-0

SMILES

O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OCCC(O)CO

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Indirubin Derivative E804
Cat. No.:
HY-18785
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Indirubin Derivative E804

Cat. No.: HY-18785