Chlorfenapyr
Based on 1 publication(s) in Google Scholar
Chlorfenapyr is a pyrrole insecticide. Chlorfenapyr has a mode of action: the mixed function oxidase oxidizes and removes the Nethoxymethyl group to form the active metabolite, CL 303268. Chlorfenapyr is used for termite control and crop protection against a variety of insect and mite pests.
For research use only. We do not sell to patients.
- Purity: 99.39%
- CAS No.: 122453-73-0
- Formula: C15H11BrClF3N2O
- Molecular Weight:407.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chlorfenapyr
MoreAll Parasite Isoforms
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Biological Activity
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Mite |
Chlorfenapyr is a pro-insecticide and oxidative removal of the N-ethoxymethyl group of Chlorfenapyr by mixed function oxidases leads to a toxic form identified as CL 303268 which functions to uncouple oxidative phosphorylation in the mitochondria, resulting in disruption of ATP production and loss of energy leading to cell dysfunction and subsequent death of the organism. This molecule has low mammalian toxicity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 122453-73-0
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Appearance Solid
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Molecular Weight 407.61
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Formula C15H11BrClF3N2O
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Color Off-white to light yellow
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SMILES
N#CC1=C(C2=CC=C(Cl)C=C2)N(COCC)C(C(F)(F)F)=C1Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Insect Sci
Genetic and pharmacological inhibition of the Kir2A channel in diamondback moth exhibits ovicidal activity. [Abstract]2026 May 11. PMID: 42116718
Solvent & Solubility
DMSO : 250 mg/mL (613.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 6.25 mg/mL (15.33 mM); Clear solution
This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (563 KB)
- English - EN (563 KB)
- Français - FR (563 KB)
- Deutsch - DE (563 KB)
- Norwegian - NO (563 KB)
- Español - ES (563 KB)
- Swedish - SV (563 KB)
- Italian - IT (563 KB)
- Korean - KR (563 KB)
- Portuguese - PT (563 KB)
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Handling Instructions (2659 KB)
References
[1]. Byung Hyun Baek, et al. Chlorfenapyr-Induced Toxic Leukoencephalopathy with Radiologic Reversibility: A Case Report and Literature Review. Korean J Radiol. 2016 Mar-Apr;17(2):277-80. [Content Brief]
[2]. Kamaraju Raghavendra, et al. Chlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors. Malar J. 2011 Jan 25;10:16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4533 mL | 12.2666 mL | 24.5333 mL | 61.3331 mL |
| 5 mM | 0.4907 mL | 2.4533 mL | 4.9067 mL | 12.2666 mL | |
| 10 mM | 0.2453 mL | 1.2267 mL | 2.4533 mL | 6.1333 mL | |
| 15 mM | 0.1636 mL | 0.8178 mL | 1.6356 mL | 4.0889 mL | |
| 20 mM | 0.1227 mL | 0.6133 mL | 1.2267 mL | 3.0667 mL | |
| 25 mM | 0.0981 mL | 0.4907 mL | 0.9813 mL | 2.4533 mL | |
| 30 mM | 0.0818 mL | 0.4089 mL | 0.8178 mL | 2.0444 mL | |
| 40 mM | 0.0613 mL | 0.3067 mL | 0.6133 mL | 1.5333 mL | |
| 50 mM | 0.0491 mL | 0.2453 mL | 0.4907 mL | 1.2267 mL | |
| 60 mM | 0.0409 mL | 0.2044 mL | 0.4089 mL | 1.0222 mL | |
| 80 mM | 0.0307 mL | 0.1533 mL | 0.3067 mL | 0.7667 mL | |
| 100 mM | 0.0245 mL | 0.1227 mL | 0.2453 mL | 0.6133 mL |
Chlorfenapyr Related Classifications
HY-B0840 Related Classifications
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