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Deschloroclozapine

86 Cited Publications
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Based on 86 publication(s) in Google Scholar

Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist, with blood-brain barrier permeability. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.

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  • Purity: 99.93%
  • CAS No.: 1977-07-7
  • Formula: C18H20N4
  • Molecular Weight:292.39
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Deschloroclozapine Chemical Structure
    Deschloroclozapine Chemical Structure
  • Experimental Validation Results for Deschloroclozapine
  • Experimental Validation Results for Deschloroclozapine
  • Experimental Validation Results for Deschloroclozapine
  • Experimental Validation Results for Deschloroclozapine
  • Experimental Validation Results for Deschloroclozapine
CAS No.: 1977-07-7
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  • Deschloroclozapine Chemical Structure
    Deschloroclozapine Chemical Structure
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    Deschloroclozapine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]

    Customer Validation
     Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐, Gi + saline‐ and Gi + DCZ‐treated mice displayed normal sociability.

  • 1/16

    Deschloroclozapine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]

    Customer Validation
     Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐ and Gi + saline ‐treated mice displayed a marked preference for novel conspecifics, Gi + DCZ‐treated mice did not differentiate between familiar and novel mice.

  • 1/16

    Deschloroclozapine purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 May 14:8:0701. [Abstract]

    Customer Validation
     Representative immunofluorescent images of c-Fos (Green) in mCherry-positive MPOA GABAergic neurons (red) after saline or Deschloroclozapine (DCZ) (100 μg/kg; i.p.) treatment in GAD2-IRES-Cre mice.

  • 1/16

    Deschloroclozapine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578. [Abstract]

    Customer Validation
     Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) caused an increase in SST interneuron responses in mice.

  • 1/16

    Deschloroclozapine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578. [Abstract]

    Customer Validation
     Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) reduced activity in VIP interneurons and prevented S1 potentiation upon RWS stimulation alone. In the presence of DCZ, RWS stimulation suppresses L2/3 pyramidal cell potentiation, and even causes depression, even when the CF is not co-activated.

  • Deschloroclozapine