1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
    Serotonin Transporter
  3. Deschloroclozapine

Deschloroclozapine 

Cat. No.: HY-42110 Purity: 99.79%
Handling Instructions

Deschloroclozapine is a potent and selective chemogenetic actuator. Deschloroclozapine is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively. Deschloroclozapine is also a selective, high-affinity, metabolically stable, and brain-penetrable Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist.

For research use only. We do not sell to patients.

Deschloroclozapine Chemical Structure

Deschloroclozapine Chemical Structure

CAS No. : 1977-07-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

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Description

Deschloroclozapine is a potent and selective chemogenetic actuator. Deschloroclozapine is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively[1]. Deschloroclozapine is also a selective, high-affinity, metabolically stable, and brain-penetrable Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist[2].

IC50 & Target

Ki: 200 nM (Dopamne D1), 2500 nM (Dopamne D2), 420 nM (Dopamne D4), 39 nM (Serotonin S2A), 84 nM (Serotonin S2C), 200 nM (Serotonin S3)[1]

Molecular Weight

292.38

Formula

C₁₈H₂₀N₄

CAS No.

1977-07-7

SMILES

CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (284.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4202 mL 17.1010 mL 34.2021 mL
5 mM 0.6840 mL 3.4202 mL 6.8404 mL
10 mM 0.3420 mL 1.7101 mL 3.4202 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

DeschloroclozapineDopamine ReceptorSerotonin Transporter5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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Deschloroclozapine
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HY-42110
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