Deschloroclozapine dihydrochloride

Name: Deschloroclozapine dihydrochloride
Brand: MedChemExpress
SKU: HY-42110A
Rating: 5.0 (35 reviews)

Cat. No.: HY-42110A Purity: 98.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K_i of 6.3 and 4.2 nM, respectively. [¹¹C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.

For research use only. We do not sell to patients.

Deschloroclozapine dihydrochloride Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 35 publication(s) in Google Scholar

Other Forms of Deschloroclozapine dihydrochloride:

Deschloroclozapine In-stock

35 Publications Citing Use of MCE Deschloroclozapine dihydrochloride

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

365.30

Formula

C₁₈H₂₂Cl₂N₄

Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (273.75 mM; Need ultrasonic)

DMSO : 100 mg/mL (273.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7375 mL	13.6874 mL	27.3748 mL
5 mM	0.5475 mL	2.7375 mL	5.4750 mL
10 mM	0.2737 mL	1.3687 mL	2.7375 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.94%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (272 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475. [Content Brief]

[2]. Hu F, et al. ¹⁸F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047. [Content Brief]

[3]. Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.7375 mL	13.6874 mL	27.3748 mL	68.4369 mL
	5 mM	0.5475 mL	2.7375 mL	5.4750 mL	13.6874 mL
	10 mM	0.2737 mL	1.3687 mL	2.7375 mL	6.8437 mL
	15 mM	0.1825 mL	0.9125 mL	1.8250 mL	4.5625 mL
	20 mM	0.1369 mL	0.6844 mL	1.3687 mL	3.4218 mL
	25 mM	0.1095 mL	0.5475 mL	1.0950 mL	2.7375 mL
	30 mM	0.0912 mL	0.4562 mL	0.9125 mL	2.2812 mL
	40 mM	0.0684 mL	0.3422 mL	0.6844 mL	1.7109 mL
	50 mM	0.0547 mL	0.2737 mL	0.5475 mL	1.3687 mL
	60 mM	0.0456 mL	0.2281 mL	0.4562 mL	1.1406 mL
	80 mM	0.0342 mL	0.1711 mL	0.3422 mL	0.8555 mL
	100 mM	0.0274 mL	0.1369 mL	0.2737 mL	0.6844 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.