Deschloroclozapine dihydrochloride

Name: Deschloroclozapine dihydrochloride
Brand: MedChemExpress
SKU: HY-42110A
Rating: 5.0 (83 reviews)

Cat. No.: HY-42110A Purity: 99.87%: Data Sheet
COA

SDS
Handling Instructions
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Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K_i of 6.3 and 4.2 nM, respectively. [¹¹C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 83 publication(s) in Google Scholar

Other Forms of Deschloroclozapine dihydrochloride:

Deschloroclozapine In-stock

83 Publications Citing Use of MCE Deschloroclozapine dihydrochloride

In Vivo Efficacy Study

: Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]; Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐, Gi + saline‐ and Gi + DCZ‐treated mice displayed normal sociability.

: Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]; Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐ and Gi + saline ‐treated mice displayed a marked preference for novel conspecifics, Gi + DCZ‐treated mice did not differentiate between familiar and novel mice.

: Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 May 14:8:0701. [Abstract]; Representative immunofluorescent images of c-Fos (Green) in mCherry-positive MPOA GABAergic neurons (red) after saline or Deschloroclozapine (DCZ) (100 μg/kg; i.p.) treatment in GAD2-IRES-Cre mice.

: Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578.; Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) caused an increase in SST interneuron responses in mice.

: Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578.; Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) reduced activity in VIP interneurons and prevented S1 potentiation upon RWS stimulation alone. In the presence of DCZ, RWS stimulation suppresses L2/3 pyramidal cell potentiation, and even causes depression, even when the CF is not co-activated.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

365.30

Formula

C₁₈H₂₂Cl₂N₄

Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (273.75 mM; Need ultrasonic)

DMSO : 80 mg/mL (219.00 mM; ultrasonic and adjust pH to 7 with 1 M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7375 mL	13.6874 mL	27.3748 mL
5 mM	0.5475 mL	2.7375 mL	5.4750 mL
10 mM	0.2737 mL	1.3687 mL	2.7375 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (13.69 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (13.69 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (253 KB) HNMR (291 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475. [Content Brief]

[2]. Hu F, et al. ¹⁸F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047. [Content Brief]

[3]. Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.7375 mL	13.6874 mL	27.3748 mL	68.4369 mL
	5 mM	0.5475 mL	2.7375 mL	5.4750 mL	13.6874 mL
	10 mM	0.2737 mL	1.3687 mL	2.7375 mL	6.8437 mL
	15 mM	0.1825 mL	0.9125 mL	1.8250 mL	4.5625 mL
	20 mM	0.1369 mL	0.6844 mL	1.3687 mL	3.4218 mL
	25 mM	0.1095 mL	0.5475 mL	1.0950 mL	2.7375 mL
	30 mM	0.0912 mL	0.4562 mL	0.9125 mL	2.2812 mL
	40 mM	0.0684 mL	0.3422 mL	0.6844 mL	1.7109 mL
	50 mM	0.0547 mL	0.2737 mL	0.5475 mL	1.3687 mL
	60 mM	0.0456 mL	0.2281 mL	0.4562 mL	1.1406 mL
	80 mM	0.0342 mL	0.1711 mL	0.3422 mL	0.8555 mL
	100 mM	0.0274 mL	0.1369 mL	0.2737 mL	0.6844 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.