Deschloroclozapine dihydrochloride
Based on 87 publication(s) in Google Scholar
Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist, with blood-brain barrier permeability. Deschloroclozapine dihydrochloride binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine dihydrochloride is developed as a promising PET tracer for DREADD imaging.
For research use only. We do not sell to patients.
- Purity: 99.87%
- Formula: C18H22Cl2N4
- Molecular Weight:365.30
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Deschloroclozapine dihydrochloride
More- Nature. 2025 Aug;644(8076):463-472. [Abstract]
- Nature. 2025 Jun;642(8067):411-420. [Abstract]
- Cell. 2025 Nov 26;188(24):6754-6773.e29. [Abstract]
- Cell. 2023 Nov 22;186(24):5394-5410.e18. [Abstract]
- Cell Metab. 2026 Jan 27:S1550-4131(25)00586-8. [Abstract]
- Cell Res. 2026 Mar 23. [Abstract]
- Cell Stem Cell. 2026 May 25:S1934-5909(26)00160-8. [Abstract]
- Nat Neurosci. 2025 Feb;28(2):320-335. [Abstract]
- Nat Neurosci. 2020 Sep;23(9):1157-1167. [Abstract]
- Nat Commun. 2023 Oct 24;14(1):6758. [Abstract]
- Nat Commun. 2023 Jul 24;14(1):4456. [Abstract]
- Nat Commun. 2023 Feb 28;14(1):971. [Abstract]
- Nat Commun. 2023 Feb 24;14(1):1066. [Abstract]
- Nat Commun. 2022 Nov 4;13(1):6662. [Abstract]
- Nat Commun. 2022 Apr 25;13(1):2233. [Abstract]
- Neuron. 2026 Jan 16:S0896-6273(25)00926-2. [Abstract]
- Neuron. 2024 Dec 4;112(23):3924-3939.e5. [Abstract]
- Neuron. 2024 Nov 6;112(21):3651-3664.e8. [Abstract]
- Neuron. 2022 Apr 20;110(8):1400-1415.e6. [Abstract]
- Neuron. 2021 Oct 20;109(20):3312-3322.e5. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]
- Sci Adv. 2024 Jul 19;10(29):eadp5239. [Abstract]
- Research (Wash D C). 2025 May 14:8:0701. [Abstract]
- Cell Rep. 2026 Jun 20;45(7):117590. [Abstract]
- Cell Rep. 2026 Mar 15;45(3):117105. [Abstract]
- Curr Biol. 2026 Feb 2;36(3):692-706.e6. [Abstract]
- Curr Biol. 2025 Oct 29:S0960-9822(25)01311-9. [Abstract]
- Neuropsychopharmacology. 2024 Dec;49(13):2022-2031. [Abstract]
- Neuropsychopharmacology. 2020 Oct;45(11):1793-1798. [Abstract]
- PLoS Biol. 2025 Dec 18;23(12):e3003576. [Abstract]
- Acta Neuropathol Commun. 2024 Nov 22;12(1):179. [Abstract]
- Cell Rep Methods. 2024 Oct 21;4(10):100881. [Abstract]
- Cell Biol Toxicol. 2025 May 13;41(1):83. [Abstract]
- Front Aging Neurosci. 2023 Mar 23:15:1142055. [Abstract]
- Neuropharmacology. 2023 Sep 1:235:109576. [Abstract]
- J Cereb Blood Flow Metab. 2021 Oct;41(10):2571-2582. [Abstract]
- J Neurochem. 2025 Dec;169(12):e70334. [Abstract]
- iScience. 2026 Jun 10;29(6):116321. [Abstract]
- iScience. 2021 Aug 30;24(9):103066. [Abstract]
- ACS Pharmacol Transl Sci. 2025 Jun 6;8(7):2048-2060. [Abstract]
- IUBMB Life. 2024 Dec;76(12):1209-1222. [Abstract]
- Behav Brain Funct. 2025 Nov 4;21(1):36. [Abstract]
- Behav Brain Res. 2023 Oct 18:455:114674. [Abstract]
- J Dig Dis. 2025 Apr 14. [Abstract]
- eNeuro. 2025 Feb 7:ENEURO.0359-24.2025. [Abstract]
- eNeuro. 2023 Oct 24;10(10):ENEURO.0162-23.2023. [Abstract]
- Eur J Neurosci. 2023 Oct;58(8):3737-3750. [Abstract]
- bioRxiv. 2026 Jul 5:2026.07.05.735345.
- bioRxiv. 2026 Mar 26.
- bioRxiv. 2026 Jan 31:2026.01.28.702128. [Abstract]
- bioRxiv. 2026 Jan 21.
- bioRxiv. 2025 Nov 2:2025.04.18.649578. [Abstract]
- bioRxiv. 2025 Oct 17.
- bioRxiv. 2025 Oct 9:2025.10.08.681007. [Abstract]
- bioRxiv. 2025 Sep 6.
- University of Iowa. 2025.
- University of Utah. 2025.
- University of British Columbia. 2025.
- bioRxiv. 2025 Aug 06.
- bioRxiv. 2025 Aug 07.
- bioRxiv. 2025 Jun 8:2025.03.13.643119. [Abstract]
- SSRN. 2025 Jun 20.
- bioRxiv. 2025 Jun 27:2025.06.26.661815. [Abstract]
- bioRxiv. 2025 May 02.
- bioRxiv. 2024 November 03.
- bioRxiv. 2024 Nov 3:2024.11.02.621692. [Abstract]
- bioRxiv. 2024 July 02.
- bioRxiv. 2024 Jun 27:2024.06.22.600167. [Abstract]
- bioRxiv. 2024 Jun 28:2024.06.28.601172. [Abstract]
- bioRxiv. 2024 Mar 12:2024.03.09.584200. [Abstract]
- bioRxiv. 2024 Feb 12:2024.02.12.579861. [Abstract]
- bioRxiv. 2023 Dec 22.
- The University of Chicago. 2023 Dec.
- bioRxiv. 2023 Nov 17:2023.11.17.567492. [Abstract]
- bioRxiv. 2023 Nov 17.
- bioRxiv. 2023 Sep 15:2023.06.21.545778. [Abstract]
- Research Square Preprint. 2023 Jul 24.
- bioRxiv. 2023 Jun 7:2023.06.06.543911. [Abstract]
- bioRxiv. 2023 May 23.
- bioRxiv. 2023 Apr 24.
- bioRxiv. 2023 Mar 6.
- Res Sq. 2023 Mar 27:rs.3.rs-2729263. [Abstract]
- Neuromethods. 2023 Feb 7.
- bioRxiv. July 19, 2021.
- bioRxiv. November 25, 2021.
- Patent. US20210275696A1.
- bioRxiv. 2020 May 18.
Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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IF
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Description
IC50 & Target
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mAChR3 |
mAChR4 |
In Vitro
Designer Receptors Exclusively Activated by Designer Drugs (DREADD) are a chemogenetic approach for remote manipulation of neuronal activity in freely-moving animals. DREADDs comprise mutated G protein-coupled receptors (GPCRs) that do not respond to their endogenous neurotransmitter, but do respond to an otherwise “inert” exogenous substance[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Deschloroclozapine (0.1 mg/kg; i.m) dihydrochloride is effective at activating DREADD receptors in vivo and reversibly inducing behavioral effects in monkeys[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 365.30
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Formula C18H22Cl2N4
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Color Light yellow to yellow
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SMILES
CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (87)
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Journal Impact Factor
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Most Recent
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Nature
2025 Aug;644(8076):463-472. PMID: 40437091 -
Nature
2025 Jun;642(8067):411-420. PMID: 40175553 -
Cell
2025 Nov 26;188(24):6754-6773.e29. PMID: 41138728 -
Cell
Circuit-specific gene therapy reverses core symptoms in a primate Parkinson's disease model. [Abstract]2023 Nov 22;186(24):5394-5410.e18. PMID: 37922901 -
Cell Metab
Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis. [Abstract]2026 Jan 27:S1550-4131(25)00586-8. PMID: 41605214 -
Cell Res
Social status impacts T-cell responses through synapse strength in the prefrontal cortex. [Abstract]2026 Mar 23. PMID: 41866615 -
Cell Stem Cell
2026 May 25:S1934-5909(26)00160-8. PMID: 42184825 -
Nat Neurosci
2025 Feb;28(2):320-335. PMID: 39627537 -
Nat Neurosci
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. [Abstract]2020 Sep;23(9):1157-1167. PMID: 32632286 -
Nat Commun
A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination. [Abstract]2023 Oct 24;14(1):6758. PMID: 37875465 -
Nat Commun
2023 Jul 24;14(1):4456. PMID: 37488119 -
Nat Commun
2023 Feb 28;14(1):971. PMID: 36854724 -
Nat Commun
An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats. [Abstract]2023 Feb 24;14(1):1066. PMID: 36828816 -
Nat Commun
Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal. [Abstract]2022 Nov 4;13(1):6662. PMID: 36333323 -
Nat Commun
Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia. [Abstract]2022 Apr 25;13(1):2233. PMID: 35468893 -
Neuron
Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides fragilis. [Abstract]2026 Jan 16:S0896-6273(25)00926-2. PMID: 41547348 -
Neuron
A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice. [Abstract]2024 Dec 4;112(23):3924-3939.e5. PMID: 39389052 -
Neuron
2024 Nov 6;112(21):3651-3664.e8. PMID: 39241779 -
Neuron
Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset. [Abstract]2022 Apr 20;110(8):1400-1415.e6. PMID: 35114101 -
Neuron
Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network. [Abstract]2021 Oct 20;109(20):3312-3322.e5. PMID: 34672984 -
Adv Sci (Weinh)
Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit. [Abstract]2025 Apr;12(13):e2406192. PMID: 39951247
Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]
Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐, Gi + saline‐ and Gi + DCZ‐treated mice displayed normal sociability.
Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]
Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐ and Gi + saline ‐treated mice displayed a marked preference for novel conspecifics, Gi + DCZ‐treated mice did not differentiate between familiar and novel mice.
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Sci Adv
Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury. [Abstract]2024 Jul 19;10(29):eadp5239. PMID: 39028822 -
Research (Wash D C)
The Hypothalamic Medial Preoptic Area-Paraventricular Nucleus Circuit Modulates Depressive-Like Behaviors in a Mouse Model of Postpartum Depression. [Abstract]2025 May 14:8:0701. PMID: 40370500
Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 May 14:8:0701. [Abstract]
Representative immunofluorescent images of c-Fos (Green) in mCherry-positive MPOA GABAergic neurons (red) after saline or Deschloroclozapine (DCZ) (100 μg/kg; i.p.) treatment in GAD2-IRES-Cre mice.
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Cell Rep
Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations. [Abstract]2026 Jun 20;45(7):117590. PMID: 42322609 -
Cell Rep
2026 Mar 15;45(3):117105. PMID: 41838719 -
Curr Biol
Motivation under aversive conditions is regulated by a striatopallidal pathway in primates. [Abstract]2026 Feb 2;36(3):692-706.e6. PMID: 41519124 -
Curr Biol
2025 Oct 29:S0960-9822(25)01311-9. PMID: 41167195 -
Neuropsychopharmacology
Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats. [Abstract]2024 Dec;49(13):2022-2031. PMID: 39080457 -
Neuropsychopharmacology
Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. [Abstract]2020 Oct;45(11):1793-1798. PMID: 32193513 -
PLoS Biol
Paralogs of Slitrk cell adhesion molecules configure excitatory synapse specificity via distinct cellular mechanisms. [Abstract]2025 Dec 18;23(12):e3003576. PMID: 41411344 -
Acta Neuropathol Commun
2024 Nov 22;12(1):179. PMID: 39578917 -
Cell Rep Methods
Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior. [Abstract]2024 Oct 21;4(10):100881. PMID: 39437713 -
Cell Biol Toxicol
Activation of CaMKII+ neurons in the paramedian raphe nucleus promotes general anesthesia in male mice. [Abstract]2025 May 13;41(1):83. PMID: 40360778 -
Front Aging Neurosci
Activation of ventral tegmental area vesicular GABA transporter (Vgat) neurons alleviates social defeat stress-induced anxiety in APP/PS1 mice. [Abstract]2023 Mar 23:15:1142055. PMID: 37032820 -
Neuropharmacology
2023 Sep 1:235:109576. PMID: 37164226 -
J Cereb Blood Flow Metab
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain. [Abstract]2021 Oct;41(10):2571-2582. PMID: 33853405 -
J Neurochem
Beta-Arrestin2-Biased Activation by Pilocarpine Suppresses Microglial Inflammatory Response. [Abstract]2025 Dec;169(12):e70334. PMID: 41457680 -
iScience
2026 Jun 10;29(6):116321. PMID: 42305597 -
iScience
Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets. [Abstract]2021 Aug 30;24(9):103066. PMID: 34568790 -
ACS Pharmacol Transl Sci
Critical Residues in the Gβ Subunit Mediate Selective Recruitment of the Gαq Heterotrimer to Activated G Protein-Coupled Receptors. [Abstract]2025 Jun 6;8(7):2048-2060. PMID: 40672669 -
IUBMB Life
Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function. [Abstract]2024 Dec;76(12):1209-1222. PMID: 39223969 -
Behav Brain Funct
Cannabinoid type 1 receptors in the mice prefrontal cortex regulate object location memory acquisition via GABAergic neurons. [Abstract]2025 Nov 4;21(1):36. PMID: 41188973 -
Behav Brain Res
Comparison of three DREADD agonists acting on Gq-DREADDs in the ventral tegmental area to alter locomotor activity in tyrosine hydroxylase:Cre male and female rats. [Abstract]2023 Oct 18:455:114674. PMID: 37722510 -
J Dig Dis
DREADDs-Based Chemogenetics Induced Slow Transit Constipation via Inhibition of Enteric Neurons. [Abstract]2025 Apr 14. PMID: 40223443 -
eNeuro
Modulation of extrinsic and intrinsic signaling together with neuronal activation enhances forelimb motor recovery after cervical spinal cord injury. [Abstract]2025 Feb 7:ENEURO.0359-24.2025. PMID: 39919817 -
eNeuro
The role of GABA in the in the dorsal striatum-raphe nucleus circuit regulating stress vulnerability in male mice with high levels of Shati/Nat8l. [Abstract]2023 Oct 24;10(10):ENEURO.0162-23.2023. PMID: 37813564 -
Eur J Neurosci
Contribution of dorsal versus ventral hippocampus to the hierarchical modulation of goal-directed actions in rats. [Abstract]2023 Oct;58(8):3737-3750. PMID: 37697949 -
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bioRxiv
The lateral septum orchestrates state-dependent modulation of associative threat memory dynamics across the ovarian hormone cycle. [Abstract]2026 Jan 31:2026.01.28.702128. PMID: 41659481 -
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bioRxiv
Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex. [Abstract]2025 Nov 2:2025.04.18.649578. PMID: 41040356
Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578. [Abstract]
Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) caused an increase in SST interneuron responses in mice.
Deschloroclozapine dihydrochloride purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578. [Abstract]
Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) reduced activity in VIP interneurons and prevented S1 potentiation upon RWS stimulation alone. In the presence of DCZ, RWS stimulation suppresses L2/3 pyramidal cell potentiation, and even causes depression, even when the CF is not co-activated.
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bioRxiv
2025 Oct 9:2025.10.08.681007. PMID: 41332577 -
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bioRxiv
Co-release of opposing signaling molecules controls the escalation and release of aggression. [Abstract]2025 Jun 8:2025.03.13.643119. PMID: 40502180 -
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bioRxiv
Chemogenetic inhibition of amygdala to ventrolateral prefrontal cortex communication selectively impacts contingent learning. [Abstract]2025 Jun 27:2025.06.26.661815. PMID: 40666866 -
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bioRxiv
Pyramidal cell types and 5-HT2A receptors are essential for psilocybin's lasting drug action. [Abstract]2024 Nov 3:2024.11.02.621692. PMID: 39554087 -
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bioRxiv
Forelimb motor recovery by modulating extrinsic and intrinsic signaling as well as neuronal activity after the cervical spinal cord injury. [Abstract]2024 Jun 27:2024.06.22.600167. PMID: 38979293 -
bioRxiv
Layer Va neurons, as major presynaptic partners of corticospinal neurons, play critical roles in skilled movements. [Abstract]2024 Jun 28:2024.06.28.601172. PMID: 38979259 -
bioRxiv
An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning. [Abstract]2024 Mar 12:2024.03.09.584200. PMID: 38559104 -
bioRxiv
Chemogenetic activation of microglial Gi signaling decreases microglial surveillance and impairs neuronal synchronization. [Abstract]2024 Feb 12:2024.02.12.579861. PMID: 38405754 -
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bioRxiv
2023 Nov 17:2023.11.17.567492. PMID: 38076986 -
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bioRxiv
The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation. [Abstract]2023 Sep 15:2023.06.21.545778. PMID: 37745436 -
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bioRxiv
DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates. [Abstract]2023 Jun 7:2023.06.06.543911. PMID: 37333300 -
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Res Sq
Direct Thalamic Inputs to Hippocampal CA1 Transmit a Signal That Suppresses Ongoing Contextual Fear Memory Retrieval. [Abstract]2023 Mar 27:rs.3.rs-2729263. PMID: 37034716 -
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Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (273.75 mM; Need ultrasonic)
DMSO : 80 mg/mL (219.00 mM; ultrasonic and adjust pH to 7 with 1 M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (13.69 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (13.69 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475. [Content Brief]
[2]. Hu F, et al. 18F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047. [Content Brief]
[3]. Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.7375 mL | 13.6874 mL | 27.3748 mL | 68.4369 mL |
| 5 mM | 0.5475 mL | 2.7375 mL | 5.4750 mL | 13.6874 mL | |
| 10 mM | 0.2737 mL | 1.3687 mL | 2.7375 mL | 6.8437 mL | |
| 15 mM | 0.1825 mL | 0.9125 mL | 1.8250 mL | 4.5625 mL | |
| 20 mM | 0.1369 mL | 0.6844 mL | 1.3687 mL | 3.4218 mL | |
| 25 mM | 0.1095 mL | 0.5475 mL | 1.0950 mL | 2.7375 mL | |
| 30 mM | 0.0912 mL | 0.4562 mL | 0.9125 mL | 2.2812 mL | |
| 40 mM | 0.0684 mL | 0.3422 mL | 0.6844 mL | 1.7109 mL | |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5475 mL | 1.3687 mL | |
| 60 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1406 mL | |
| 80 mM | 0.0342 mL | 0.1711 mL | 0.3422 mL | 0.8555 mL | |
| 100 mM | 0.0274 mL | 0.1369 mL | 0.2737 mL | 0.6844 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Deschloroclozapine dihydrochloride Related Classifications
HY-42110A Related Classifications
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