1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Lactate Dehydrogenase
    DNA/RNA Synthesis
  3. hDHODH-IN-2

hDHODH-IN-2 

Cat. No.: HY-135654
Handling Instructions

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity.

For research use only. We do not sell to patients.

hDHODH-IN-2 Chemical Structure

hDHODH-IN-2 Chemical Structure

CAS No. : 183946-00-1

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Description

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].

In Vitro

hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC50) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)[1].

Molecular Weight

304.34

Formula

C₁₉H₁₆N₂O₂

CAS No.

183946-00-1

SMILES

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=C(C3CC3)\O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

hDHODH-IN-2Lactate DehydrogenaseDNA/RNA SynthesisLDHLeflunomideanaloguehDHODHanti-inflammatoryInhibitorinhibitorinhibit

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