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Cat. No.: HY-135654

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hDHODH-IN-2

Name: hDHODH-IN-2
Brand: MedChemExpress
SKU: HY-135654
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity.

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CAS No.: 183946-00-1
Formule: C₁₉H₁₆N₂O₂
Masse moléculaire:304.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

hDHODH-IN-2 Chemical Structure

CAS No.: 183946-00-1

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références
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Activité biologique

Description

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity^[1]^[2].

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In Vitro

hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC₅₀) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 183946-00-1
Masse moléculaire 304.34
Formule C₁₉H₁₆N₂O₂
SMILES

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=C(C3CC3)\O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2026 May 21.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. [Content Brief]

[2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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hDHODH-IN-2

1 Cited Publications

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références

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hDHODH-IN-2

Publications Citing Use of MedChemExpress (MCE) hDHODH-IN-2

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