1. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  3. hDHODH-IN-2

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity.

For research use only. We do not sell to patients.

hDHODH-IN-2 Chemical Structure

hDHODH-IN-2 Chemical Structure

CAS No. : 183946-00-1

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Description

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].

In Vitro

hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC50) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.34

Formula

C19H16N2O2

CAS No.
SMILES

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=C(C3CC3)\O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
hDHODH-IN-2
Cat. No.:
HY-135654
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