183946-00-1
183946-00-1
Chemical Structure
hDHODH-IN-2
- CAS No.: 183946-00-1
- Formula:C19H16N2O2
- Molecular Weight:304.34
IUPAC Name: (Z)-N-([1,1'-biphenyl]-4-yl)-2-cyano-3-cyclopropyl-3-hydroxyacrylamide
InChIKey: CAGGGMPTWTUYHZ-ZCXUNETKSA-N
SMILES: O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=C(C3CC3)\O
Biological Activity: hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].
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hDHODH-IN-2 | hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity. | |||||||||||||||||||||
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References
- [1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. [Content Brief]
- [2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960. [Content Brief]
Keywords
