Sodium 2-hydroxybutanoate
Based on 1 publication(s) in Google Scholar
Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite. Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia. Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury.
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- Pureté : 98.0%
- CAS No.: 5094-24-6
- Formule: C4H7NaO3
- Masse moléculaire:126.09
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sodium 2-hydroxybutanoate
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Activité biologique
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
Sodium 2-hydroxybutanoate is synthesized as coproduct of insulin resistance, causes insulin signaling impairment and mitochondrial overload[2].
Sodium 2-hydroxybutanoate (0-40 mM) enhances the cell viabilities and decreases the AP-induced cytotoxicities of BRL3A, AML12 and mice primary hepatocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BRL3A, AML12, mice primary hepatocytes
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Concentration:0-40 mM
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Incubation Time:24-48 h
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Result:Decreased AP-induced toxicity in AML12, BRL3A and mice primary hepatocytes.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AP-induced liver injury in C57 mice[3]
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Dosage:250 mg/kg/day
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Administration:i.p. for 3 days
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Result:Prevented AP-induced liver injury.
Chemical Information
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CAS No. 5094-24-6
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Appearance Solid
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Masse moléculaire 126.09
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Formule C4H7NaO3
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Color White to yellow
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SMILES
CCC(O)C(O[Na])=O
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Synonyms
2-Hydroxybutyric acid sodium
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227
Solvant et solubilité
In Vitro:
H2O : 50 mg/mL (396.54 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (793.08 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (283 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Landaas S, et al. The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta. 1975 Jan 6;58(1):23-32. [Content Brief]
[2]. Shantavasinkul PC, et al., Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid. Surg Obes Relat Dis. 2018 Aug;14(8):1126-1132. [Content Brief]
[3]. Zheng N, et al., Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid. J Pharm Anal. 2020 Dec;10(6):560-570. [Content Brief]
[4]. Wang F, et al., Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia. Open Life Sci. 2023 Feb 28;18(1):20220572. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.9308 mL | 39.6542 mL | 79.3084 mL | 198.2711 mL |
| 5 mM | 1.5862 mL | 7.9308 mL | 15.8617 mL | 39.6542 mL | |
| 10 mM | 0.7931 mL | 3.9654 mL | 7.9308 mL | 19.8271 mL | |
| 15 mM | 0.5287 mL | 2.6436 mL | 5.2872 mL | 13.2181 mL | |
| 20 mM | 0.3965 mL | 1.9827 mL | 3.9654 mL | 9.9136 mL | |
| 25 mM | 0.3172 mL | 1.5862 mL | 3.1723 mL | 7.9308 mL | |
| 30 mM | 0.2644 mL | 1.3218 mL | 2.6436 mL | 6.6090 mL | |
| 40 mM | 0.1983 mL | 0.9914 mL | 1.9827 mL | 4.9568 mL | |
| 50 mM | 0.1586 mL | 0.7931 mL | 1.5862 mL | 3.9654 mL | |
| 60 mM | 0.1322 mL | 0.6609 mL | 1.3218 mL | 3.3045 mL | |
| 80 mM | 0.0991 mL | 0.4957 mL | 0.9914 mL | 2.4784 mL | |
| 100 mM | 0.0793 mL | 0.3965 mL | 0.7931 mL | 1.9827 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium 2-hydroxybutanoate Related Classifications
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