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Cat. No.: HY-N10206

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11-epi-Chaetomugilin I

11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line.

For research use only. We do not sell to patients.

CAS No.: 1319729-88-8
Formula: C₂₂H₂₇ClO₅
Molecular Weight:406.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

11-epi-Chaetomugilin I Chemical Structure

CAS No.: 1319729-88-8

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Microbial Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.9 μM Compound: 4	Inhibition of TNFalpha-induced NF-kappaB activity (unknown origin) transfected in HEK293 cells after 6 hrs by luciferase reporter gene assay Inhibition of TNFalpha-induced NF-kappaB activity (unknown origin) transfected in HEK293 cells after 6 hrs by luciferase reporter gene assay	[PMID: 26343828]
HL-60	IC₅₀	1 pM Compound: 4	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 21640594]
KB	IC₅₀	1.2 pM Compound: 4	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21640594]
L1210	IC₅₀	1.6 pM Compound: 4	Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay	[PMID: 21640594]
P388	IC₅₀	0.7 pM Compound: 4	Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay	[PMID: 21640594]
RAW264.7	IC₅₀	0.8 μM Compound: 4	Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS challenge measured after 20 hrs by Griess assay Inhibition of nitric oxide production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS challenge measured after 20 hrs by Griess assay	[PMID: 26343828]
RAW264.7	IC₅₀	6.8 μM Compound: 4	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell survival preincubated for 15 mins followed by LPS challenge measured after 20 hrs by SRB assay Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell survival preincubated for 15 mins followed by LPS challenge measured after 20 hrs by SRB assay	[PMID: 26343828]

Chemical Information

CAS No. 1319729-88-8
Molecular Weight 406.90
Formula C₂₂H₂₇ClO₅
SMILES

O=C(/C(C)=C/C)C[C@H]([C@@]1(O)C)C2=COC(/C=C/[C@H](C)[C@H](O)C)=CC2=C(C1=O)Cl
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Chaetomium globosum
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yamada T, et al. New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities. Bioorg Med Chem. 2011;19(13):4106-4113. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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11-epi-Chaetomugilin I

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

11-epi-Chaetomugilin I Related Classifications

HY-N10206 Related Classifications