Sporogen AO-1
Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC50 value of 1.53 μM, and also has certain cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 88418-12-6
- Formula: C15H20O3
- Molecular Weight:248.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>10 μM
Compound: GNF-Pf-1841
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
| KB | IC50 |
17.84 μM
Compound: 7
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Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
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[PMID: 25734623] |
| Vero | IC50 |
4.23 μM
Compound: 7
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay
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[PMID: 25734623] |
Chemical Information
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CAS No. 88418-12-6
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Molecular Weight 248.32
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Formula C15H20O3
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SMILES
CC([C@]1(C(C=C2CC[C@H]3O)=O)[C@]([C@@]2([C@H]3C)C)([H])O1)=C
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Structure Classification
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Initial Source
Aspergillus flavus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)