Levoketoconazole-d3
Based on 1 Customer Validation
Levoketoconazole-d3 ((-)-Ketoconazole-d3) is the deuterated-labeled Levoketoconazole (HY-B0105B). Levoketoconazole ((-)-Ketoconazole) is the 2S,4R enantiomer derived from racemic Ketoconazole (HY-B0105). Levoketoconazole is a potent and orally active cortisol synthesis inhibitor. Levoketoconazole inhibits key steps in cortisol and testosterone synthesis by inhibiting CYP11B1, CYP11A1, and CYP17A1. Levoketoconazole can be used for research on endogenous Cushing’s syndrome.
For research use only. We do not sell to patients.
- CAS No.: 1217766-70-5
- Formula: C26H25D3Cl2N4O4
- Molecular Weight:534.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217766-70-5
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Unlabeled CAS 65277-42-1
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Molecular Weight 534.45
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Formula C26H25D3Cl2N4O4
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SMILES
[2H]C([2H])([2H])C(N(CC1)CCN1C(C=C2)=CC=C2OC[C@H](CO3)O[C@@]3(C4=C(C=C(C=C4)Cl)Cl)CN5C=CN=C5)=O
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Synonyms
(-)-Ketoconazole-d3; (-)-Ketoconazol-d3; (-)-R 41400-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pivonello R, et al. Levoketoconazole in the treatment of patients with endogenous Cushing's syndrome: a double-blind, placebo-controlled, randomized withdrawal study (LOGICS). Pituitary. 2022 Dec;25(6):911-926. [Content Brief]
[2]. McCartney NK, et al. Levoketoconazole. Hosp Pharm. 2022 Oct;57(5):605-614. [Content Brief]
[3]. Creemers SG, et al. Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment. J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1618-e1630. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Levoketoconazole-d3 Related Classifications
HY-B0105BS Related Classifications
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