Levoketoconazole-d3
Based on 1 Customer Validation
Levoketoconazole-d3 ((-)-Ketoconazole-d3) is the deuterated-labeled Levoketoconazole (HY-B0105B). Levoketoconazole ((-)-Ketoconazole) is the 2S,4R enantiomer derived from racemic Ketoconazole (HY-B0105). Levoketoconazole is a potent and orally active cortisol synthesis inhibitor. Levoketoconazole inhibits key steps in cortisol and testosterone synthesis by inhibiting CYP11B1, CYP11A1, and CYP17A1. Levoketoconazole can be used for research on endogenous Cushing’s syndrome.
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- CAS No.: 1217766-70-5
- 화학식: C26H25D3Cl2N4O4
- 분자량:534.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217766-70-5
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Unlabeled CAS 65277-42-1
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분자량 534.45
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화학식 C26H25D3Cl2N4O4
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SMILES
[2H]C([2H])([2H])C(N(CC1)CCN1C(C=C2)=CC=C2OC[C@H](CO3)O[C@@]3(C4=C(C=C(C=C4)Cl)Cl)CN5C=CN=C5)=O
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Synonyms
(-)-Ketoconazole-d3; (-)-Ketoconazol-d3; (-)-R 41400-d3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Pivonello R, et al. Levoketoconazole in the treatment of patients with endogenous Cushing's syndrome: a double-blind, placebo-controlled, randomized withdrawal study (LOGICS). Pituitary. 2022 Dec;25(6):911-926. [Content Brief]
[2]. McCartney NK, et al. Levoketoconazole. Hosp Pharm. 2022 Oct;57(5):605-614. [Content Brief]
[3]. Creemers SG, et al. Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment. J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1618-e1630. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Levoketoconazole-d3 Related Classifications
HY-B0105BS Related Classifications
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