Sulcatone
Based on 1 Customer Validation
Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis.
For research use only. We do not sell to patients.
- Purity: 98.63%
- CAS No.: 110-93-0
- Formula: C8H14O
- Molecular Weight:126.20
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Human Endogenous Metabolite |
CYP1B1 |
A2AR |
Sulcatone (0-40 µM; 2-24 h) exhibits repellent and insecticidal activities (LC95: 17.2 µL/L) against Sitophilus zeamais adults [1].
Sulcatone (0.03-4.24 mM; 7-10 days) has MICs of 3.5, 3.8, and 3.9 mM for F. verticillioides, A. parasiticus, and A. flavus, respectively[1].
Sulcatona (1-1000 µM) can upregulate the expression of A2A adenosine receptors, inhibit the expression of CYP1B1 enzyme (10 µM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Sulcatone (10 μg; applied to filter paper strips; single dose) elicits an electrophysiological response and significantly attracts female Platypus mutatus beetles[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 110-93-0
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Appearance Liquid (Density: 0.855 g/cm3)
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Molecular Weight 126.20
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Formula C8H14O
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Color Colorless to light yellow
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SMILES
CC(CC/C=C(C)\C)=O
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Synonyms
6-Methyl-5-hepten-2-one
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (792.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (19.81 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (19.81 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Portuguese - PT (466 KB)
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Handling Instructions (2659 KB)
References
[1]. Achimón F, et al. Sulcatone as a Plant-Derived Volatile Organic Compound for the Control of the Maize Weevil and Its Associated Phytopathogenic Fungi in Stored Maize. Plants (Basel). 2024 Oct 16;13(20):2893. [Content Brief]
[3]. Gonzalez Audino P, et al. Identification of volatile emissions from Platypus mutatus (=sulcatus) (Coleoptera: Platypodidae) and their behavioral activity. J Econ Entomol. 2005 Oct;98(5):1506-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.9239 mL | 39.6197 mL | 79.2393 mL | 198.0983 mL |
| 5 mM | 1.5848 mL | 7.9239 mL | 15.8479 mL | 39.6197 mL | |
| 10 mM | 0.7924 mL | 3.9620 mL | 7.9239 mL | 19.8098 mL | |
| 15 mM | 0.5283 mL | 2.6413 mL | 5.2826 mL | 13.2066 mL | |
| 20 mM | 0.3962 mL | 1.9810 mL | 3.9620 mL | 9.9049 mL | |
| 25 mM | 0.3170 mL | 1.5848 mL | 3.1696 mL | 7.9239 mL | |
| 30 mM | 0.2641 mL | 1.3207 mL | 2.6413 mL | 6.6033 mL | |
| 40 mM | 0.1981 mL | 0.9905 mL | 1.9810 mL | 4.9525 mL | |
| 50 mM | 0.1585 mL | 0.7924 mL | 1.5848 mL | 3.9620 mL | |
| 60 mM | 0.1321 mL | 0.6603 mL | 1.3207 mL | 3.3016 mL | |
| 80 mM | 0.0990 mL | 0.4952 mL | 0.9905 mL | 2.4762 mL | |
| 100 mM | 0.0792 mL | 0.3962 mL | 0.7924 mL | 1.9810 mL |
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