4-Hydroxyatomoxetine
Based on 1 Customer Validation
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
For research use only. We do not sell to patients.
- Purity: 97.04%
- CAS No.: 435293-66-6
- Formula: C17H21NO2
- Molecular Weight:271.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1490 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor delta 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor delta 1 expressed in HEK293 cells
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[PMID: 15225731] |
| HEK293 | IC50 |
164 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor mu 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor mu 1 expressed in HEK293 cells
|
[PMID: 15225731] |
| HEK293 | IC50 |
88 nM
Compound: 7 (4-hydroxyatomoxetine)
|
Inhibitory activity against Opioid receptor kappa 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor kappa 1 expressed in HEK293 cells
|
[PMID: 15225731] |
| HEK293 | IC50 |
>5000 nM
Compound: 7 (4-hydroxyatomoxetine)
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Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cells
Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cells
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[PMID: 15225731] |
Chemical Information
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CAS No. 435293-66-6
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Appearance Solid
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Molecular Weight 271.35
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Formula C17H21NO2
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Color Off-white to yellow
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SMILES
OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (460.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children.
[2]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6853 mL | 18.4264 mL | 36.8528 mL | 92.1319 mL |
| 5 mM | 0.7371 mL | 3.6853 mL | 7.3706 mL | 18.4264 mL | |
| 10 mM | 0.3685 mL | 1.8426 mL | 3.6853 mL | 9.2132 mL | |
| 15 mM | 0.2457 mL | 1.2284 mL | 2.4569 mL | 6.1421 mL | |
| 20 mM | 0.1843 mL | 0.9213 mL | 1.8426 mL | 4.6066 mL | |
| 25 mM | 0.1474 mL | 0.7371 mL | 1.4741 mL | 3.6853 mL | |
| 30 mM | 0.1228 mL | 0.6142 mL | 1.2284 mL | 3.0711 mL | |
| 40 mM | 0.0921 mL | 0.4607 mL | 0.9213 mL | 2.3033 mL | |
| 50 mM | 0.0737 mL | 0.3685 mL | 0.7371 mL | 1.8426 mL | |
| 60 mM | 0.0614 mL | 0.3071 mL | 0.6142 mL | 1.5355 mL | |
| 80 mM | 0.0461 mL | 0.2303 mL | 0.4607 mL | 1.1516 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3685 mL | 0.9213 mL |
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