2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. 4-Hydroxyatomoxetine

4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).

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4-Hydroxyatomoxetine Chemical Structure

4-Hydroxyatomoxetine Chemical Structure

CAS No. : 435293-66-6

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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Hydroxyatomoxetine:

4-Hydroxyatomoxetine Related Antibodies

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Description

4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1][2].

Molecular Weight

271.35

Formula

C17H21NO2
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (460.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6853 mL 18.4264 mL 36.8528 mL
5 mM 0.7371 mL 3.6853 mL 7.3706 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6853 mL 18.4264 mL 36.8528 mL 92.1319 mL
5 mM 0.7371 mL 3.6853 mL 7.3706 mL 18.4264 mL
10 mM 0.3685 mL 1.8426 mL 3.6853 mL 9.2132 mL
15 mM 0.2457 mL 1.2284 mL 2.4569 mL 6.1421 mL
20 mM 0.1843 mL 0.9213 mL 1.8426 mL 4.6066 mL
25 mM 0.1474 mL 0.7371 mL 1.4741 mL 3.6853 mL
30 mM 0.1228 mL 0.6142 mL 1.2284 mL 3.0711 mL
40 mM 0.0921 mL 0.4607 mL 0.9213 mL 2.3033 mL
50 mM 0.0737 mL 0.3685 mL 0.7371 mL 1.8426 mL
60 mM 0.0614 mL 0.3071 mL 0.6142 mL 1.5355 mL
80 mM 0.0461 mL 0.2303 mL 0.4607 mL 1.1516 mL
100 mM 0.0369 mL 0.1843 mL 0.3685 mL 0.9213 mL
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4-Hydroxyatomoxetine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroxyatomoxetine435293-66-6Adrenergic ReceptorBeta ReceptorMetaboliteAtomoxetinenoradrenalinre-uptakeNETSERTDATInhibitorinhibitorinhibit

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