435293-66-6
435293-66-6
Chemical Structure
4-Hydroxyatomoxetine
- CAS No.: 435293-66-6
- Formula:C17H21NO2
- Molecular Weight:271.35
IUPAC Name: (R)-3-methyl-4-(3-(methylamino)-1-phenylpropoxy)phenol
InChIKey: PPXQPRLGNSJNJM-QGZVFWFLSA-N
SMILES: OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1
Biological Activity: 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
4-Hydroxyatomoxetine | 97.04% | 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4-Hydroxyatomoxetine-d3 | 98.89% | 4-Hydroxyatomoxetine-d3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4'-Hydroxy Atomoxetine-d3 (hemioxalate) | 4'-Hydroxy Atomoxetine-d3 (hemioxalate) is the deuterium labeled 4'-Hydroxy Atomoxetine hemioxalate. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children.
- [2]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. [Content Brief]
