1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. Adrenergic Receptor Serotonin Transporter Sodium Channel
  3. Atomoxetine hydrochloride

Atomoxetine hydrochloride  (Synonyms: Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603)

Cat. No.: HY-17385 Purity: 99.94%
COA Handling Instructions

Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.

For research use only. We do not sell to patients.

Atomoxetine hydrochloride Chemical Structure

Atomoxetine hydrochloride Chemical Structure

CAS No. : 82248-59-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 3 publication(s) in Google Scholar

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Description

Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

In Vitro

Atomoxetine (Tomoxetine) (1-100 µM; 0.5-20 seconds; tsA201 cells) hydrochloride interacts with the human heart muscle sodium channel (hNav1.5) in a state and dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atomoxetine (0.3-3 mg/kg; i.p.; 0-4 hours; male Sprague-Dawley rats) hydrochlorideincreases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression in the rat prefrontal cortex[1].
Atomoxetine (0.1-5 mg/kg; i.p. and p.o; for 14 days; spontaneously hypertensive rat) hydrochloride can improve behaviors associated with ADHD in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.3, 1 and 3 mg/kg
Administration: Intraperitoneal injection; for 4 hours
Result: Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold.
Animal Model: Spontaneously hypertensive rat (SHR)[3]
Dosage: 0.1, 0.3, 1.25 and 5.0 mg/kg
Administration: Intraperitoneal injection and oral administration; for 14 days
Result: Had non-impact on the measurement of motor activity.
Clinical Trial
Molecular Weight

291.82

Formula

C17H22ClNO

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (342.68 mM)

H2O : 50 mg/mL (171.34 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4268 mL 17.1338 mL 34.2677 mL
5 mM 0.6854 mL 3.4268 mL 6.8535 mL
10 mM 0.3427 mL 1.7134 mL 3.4268 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 8.33 mg/mL (28.54 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Atomoxetine hydrochloride
Cat. No.:
HY-17385
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