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Cat. No.: HY-181680

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ATPase-IN-8

ATPase-IN-8 is an anti-enteroviral agent that inhibits the viral non-structural protein 2C, with an IC₅₀ of 1.4 μM against CV-B3 2C ATPase. ATPase-IN-8 exhibits significant anti-enteroviral activity and acts as a potent, selective inhibitor of CV-B3 and EV-D68. ATPase-IN-8 can be used for research on enteroviral infections.

For research use only. We do not sell to patients.

CAS No.: 145294-59-3
Formula: C₁₆H₁₈INO
Molecular Weight:367.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ATPase-IN-8 Chemical Structure

CAS No.: 145294-59-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

ATPase-IN-8 (serial dilutions; 72 h) potently inhibits CV-B3 replication in HeLa CCL-2 cells with an EC₅₀ of 0.5 μM, has a CC₅₀ of 22 μM, and a selectivity index of 44^[1].
ATPase-IN-8 (serial dilutions; 72 h) potently inhibits EV-D68 replication in RD cells with an EC₅₀ of 0.4 μM, has a CC₅₀ of 23 μM, and a selectivity index of 58^[1].
ATPase-IN-8 (serial dilutions; 48 h (antiviral activity); 72 h (cytotoxicity)) inhibits EV-A71 replication in RD cells with an EC₅₀ of 8 μM, has a CC₅₀ of 23 μM, and a selectivity index of 3^[1].
ATPase-IN-8 (serial dilutions; 72 h) inhibits EV-D68 induced cytopathic effect in RD cells with an EC₅₀ of 0.6 μM^[1].
ATPase-IN-8 (0.1-10 μM; 3 days) dose-dependently reduces EV-D68 plaque formation in RD cells, with complete inhibition at concentrations of 1 μM and above^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 145294-59-3
Molecular Weight 367.22
Formula C₁₆H₁₈INO
SMILES

CNCC[C@H](OC1=CC=C(I)C=C1)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khemiri S, et al. New fluoxetine analogues as anti-enterovirus agents targeting 2C protein. Eur J Med Chem. 2026 Mar 15;306:118621.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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