1. Antibody-drug Conjugate/ADC Related
    Cytoskeleton
    Cell Cycle/DNA Damage
  2. ADC Cytotoxin
    Microtubule/Tubulin
  3. DM4-SMe

DM4-SMe 

Cat. No.: HY-130082
Handling Instructions

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM.

For research use only. We do not sell to patients.

DM4-SMe Chemical Structure

DM4-SMe Chemical Structure

CAS No. : 796073-68-2

Size Price Stock
45 mg USD 2500 Ask For Quote & Lead Time
100 mg USD 4138 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].

IC50 & Target[1]

Maytansinoids

 

Molecular Weight

826.46

Formula

C₃₉H₅₆ClN₃O₁₀S₂

CAS No.

796073-68-2

SMILES

C[[email protected]]12[[email protected]]([[email protected]@H]([[email protected]](O3)([H])C[[email protected]]([[email protected]](/C=C/C=C(C)/CC4=CC(N(C)C(C[[email protected]]2([H])OC([[email protected]](C)N(C)C(CCC(C)(C)SSC)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DM4-SMeADC CytotoxinMicrotubule/TubulinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
DM4-SMe
Cat. No.:
HY-130082
Quantity:
MCE Japan Authorized Agent: