D-Mannosamine hydrochloride
Based on 1 publication(s) in Google Scholar
D-Mannosamine ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal) hydrochloride is a six-carbon amino sugar and an amino derivative of D-mannose. D-Mannosamine hydrochloride can block mannose receptors.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 5505-63-5
- Formula: C6H14ClNO5
- Molecular Weight:215.63
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) D-Mannosamine hydrochloride
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Biological Activity
Description
In Vitro
D-Mannosamine hydrochloride (50 mM; 1 h) can significantly reduce the cellular uptake level of lipid nanoparticles (LNPs) modified with DMG-PEG2000-Mannose in DC2.4 cells, thereby confirming that DMG-PEG2000-Mannose mediates the targeted uptake of LNPs through mannose receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5505-63-5
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Appearance Solid
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Molecular Weight 215.63
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Formula C6H14ClNO5
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Color White to off-white
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SMILES
O=C[C@@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.[H]Cl
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Synonyms
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Control Release
Chitosan and mannose-modified dual-functional mRNA-LNP vaccines for robust systemic and mucosal immune responses. [Abstract]2025 Aug 10:384:113891. PMID: 40441491
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (463.76 mM)
DMSO : 25 mg/mL (115.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 4.6376 mL | 23.1879 mL | 46.3757 mL | 115.9393 mL |
| 5 mM | 0.9275 mL | 4.6376 mL | 9.2751 mL | 23.1879 mL | |
| 10 mM | 0.4638 mL | 2.3188 mL | 4.6376 mL | 11.5939 mL | |
| 15 mM | 0.3092 mL | 1.5459 mL | 3.0917 mL | 7.7293 mL | |
| 20 mM | 0.2319 mL | 1.1594 mL | 2.3188 mL | 5.7970 mL | |
| 25 mM | 0.1855 mL | 0.9275 mL | 1.8550 mL | 4.6376 mL | |
| 30 mM | 0.1546 mL | 0.7729 mL | 1.5459 mL | 3.8646 mL | |
| 40 mM | 0.1159 mL | 0.5797 mL | 1.1594 mL | 2.8985 mL | |
| 50 mM | 0.0928 mL | 0.4638 mL | 0.9275 mL | 2.3188 mL | |
| 60 mM | 0.0773 mL | 0.3865 mL | 0.7729 mL | 1.9323 mL | |
| 80 mM | 0.0580 mL | 0.2898 mL | 0.5797 mL | 1.4492 mL | |
| 100 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1594 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Mannosamine hydrochloride Related Classifications
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