CoA-S-S-CoA 

CoA-S-S-CoA is an oxidized disulfide form of Coenzyme A (HY-128851). CoA-S-S-CoA acts as a pool of disulfide reducing equivalents^[1][2].

CoA-S-S-CoA is a specific substrate for Pyrococcus-derived coenzyme A disulfide reductase (CoADR)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1533.05

C₄₂H₇₀N₁₄O₃₂P₆S₂

31664-36-5

Solid

White to off-white

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSSCCNC(CCNC([C@H](O)C(C)(C)COP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](O)[C@@H]4OP(O)(O)=O)(O)=O)(O)=O)=O)=O)=O)=O)(O)=O)(O)=O)O3

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

• [1]. Harris D R, et al. Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii: Implications for the disulfide metabolism of anaerobic hyperthermophiles[J]. The FEBS journal, 2005, 272(5): 1189-1200.

  [2]. Hummel CS, et al. Determination of coenzyme A levels in Pyrococcus furiosus and other Archaea: implications for a general role for coenzyme A in thermophiles. FEMS Microbiol Lett. 2005;252(2):229-234.  [Content Brief]