2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Dehydroaripiprazole

Dehydroaripiprazole  (Synonyms: OPC-14857; DM-14857)

Cat. No.: HY-100665 Purity: 99.66%
COA Handling Instructions

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Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.

For research use only. We do not sell to patients.

Dehydroaripiprazole Chemical Structure

Dehydroaripiprazole Chemical Structure

CAS No. : 129722-25-4

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10 mg USD 150 In-stock
25 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dehydroaripiprazole:

Dehydroaripiprazole Related Antibodies

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1 Publications Citing Use of MCE Dehydroaripiprazole

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Description

Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole[1][2][3].

IC50 & Target[4]

5-HT1A Receptor

4.2 nM (Ki)

Molecular Weight

446.37

Formula

C23H25Cl2N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (44.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2403 mL 11.2015 mL 22.4029 mL
5 mM 0.4481 mL 2.2403 mL 4.4806 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.66%

COA (243 KB) HNMR (138 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2403 mL 11.2015 mL 22.4029 mL 56.0073 mL
5 mM 0.4481 mL 2.2403 mL 4.4806 mL 11.2015 mL
10 mM 0.2240 mL 1.1201 mL 2.2403 mL 5.6007 mL
15 mM 0.1494 mL 0.7468 mL 1.4935 mL 3.7338 mL
20 mM 0.1120 mL 0.5601 mL 1.1201 mL 2.8004 mL
25 mM 0.0896 mL 0.4481 mL 0.8961 mL 2.2403 mL
30 mM 0.0747 mL 0.3734 mL 0.7468 mL 1.8669 mL
40 mM 0.0560 mL 0.2800 mL 0.5601 mL 1.4002 mL
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Dehydroaripiprazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydroaripiprazole129722-25-4OPC-14857 DM-14857OPC14857OPC 14857DM14857DM 14857DM-148575-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorMetaboliteCYP3A4CYP2D6antipsychoticInhibitorinhibitorinhibit

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