1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Aripiprazole

Aripiprazole (Synonyms: OPC-14597)

Cat. No.: HY-14546 Purity: 99.17%
Handling Instructions

Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

For research use only. We do not sell to patients.

Aripiprazole Chemical Structure

Aripiprazole Chemical Structure

CAS No. : 129722-12-9

Size Price Stock Quantity
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
200 mg USD 90 In-stock
Estimated Time of Arrival: December 31
500 mg USD 126 In-stock
Estimated Time of Arrival: December 31
1 g USD 162 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Aripiprazole:

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Description

Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

IC50 & Target

5-HT1A Receptor

4.2 nM (Ki)

In Vitro

Aripiprazole (OPC-14597) is an atypical antipsychotic medication used for the treatment of schizophrenia. Aripiprazole (OPC-14597) appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, Aripiprazole (OPC-14597) is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole (OPC-14597) has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

448.39

Formula

C₂₃H₂₇Cl₂N₃O₂

CAS No.
SMILES

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMF : 50 mg/mL (111.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2302 mL 11.1510 mL 22.3020 mL
5 mM 0.4460 mL 2.2302 mL 4.4604 mL
10 mM 0.2230 mL 1.1151 mL 2.2302 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMF    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.58 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMF    90% corn oil

    Solubility: 2.5 mg/mL (5.58 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.93%

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Keywords:

AripiprazoleOPC-14597OPC14597OPC 145975-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Aripiprazole
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