2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Aripiprazole

Aripiprazole  (Synonyms: OPC-14597)

Cat. No.: HY-14546 Purity: 99.93%
COA Handling Instructions

Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.

For research use only. We do not sell to patients.

Aripiprazole Chemical Structure

Aripiprazole Chemical Structure

CAS No. : 129722-12-9

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Aripiprazole:

Aripiprazole Related Antibodies

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Description

Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19[1][2][3][4].

IC50 & Target

5-HT1A Receptor

4.2 nM (Ki)

5-HT2A Receptor

 

5-HT2B Receptor

 

5-HT2C Receptor

 

D2 Receptor

 

D3 Receptor

 

D4 Receptor

 

In Vitro

Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation[1].
Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aripiprazole Related Antibodies
In Vivo

Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)[4]
Dosage: 0, 0.3, 1, 3 mg/kg
Administration: IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments
Result: Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
Clinical Trial
Molecular Weight

448.39

Appearance

Solid

Formula

C23H27Cl2N3O2
CAS No.
SMILES

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMF : 50 mg/mL (111.51 mM; Need ultrasonic)

DMSO : 10 mg/mL (22.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2302 mL 11.1510 mL 22.3020 mL
5 mM 0.4460 mL 2.2302 mL 4.4604 mL
10 mM 0.2230 mL 1.1151 mL 2.2302 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMF    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.58 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMF    90% corn oil

    Solubility: 2.5 mg/mL (5.58 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.93%

COA (251 KB) HNMR (180 KB) LCMS (291 KB)

Handling Instructions (2659 KB)
References
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Aripiprazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Aripiprazole129722-12-9OPC-14597OPC14597OPC 145975-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorCHO-D2L cellsAntipsychoticDopamineSerotoninPrefrontal cortexHippocampusCOVID19Inhibitorinhibitorinhibit

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