1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Aripiprazole-d8

Aripiprazole-d8  (Synonyms: OPC-14597-d8)

Cat. No.: HY-14546S Purity: ≥99.0%
COA Handling Instructions

Aripiprazole-d8 is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

For research use only. We do not sell to patients.

Aripiprazole-d<sub>8</sub> Chemical Structure

Aripiprazole-d8 Chemical Structure

CAS No. : 1089115-06-9

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1 mg USD 330 In-stock
5 mg USD 820 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Aripiprazole-d8 is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

IC50 & Target

5-HT2A Receptor

 

5-HT2C Receptor

 

Clinical Trial
Molecular Weight

456.43

Formula

C23H19D8Cl2N3O2

CAS No.
Unlabeled CAS

129722-12-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C=CC(OCCCCN3C([2H])([2H])C([2H])([2H])N(C4=CC=CC(Cl)=C4Cl)C([2H])([2H])C3([2H])[2H])=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (21.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 10 mg/mL (21.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1909 mL 10.9546 mL 21.9092 mL
5 mM 0.4382 mL 2.1909 mL 4.3818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.1909 mL 10.9546 mL 21.9092 mL 54.7729 mL
5 mM 0.4382 mL 2.1909 mL 4.3818 mL 10.9546 mL
10 mM 0.2191 mL 1.0955 mL 2.1909 mL 5.4773 mL
15 mM 0.1461 mL 0.7303 mL 1.4606 mL 3.6515 mL
20 mM 0.1095 mL 0.5477 mL 1.0955 mL 2.7386 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aripiprazole-d8
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HY-14546S
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