2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Aripiprazole monohydrate

Aripiprazole monohydrate  (Synonyms: OPC-14597 monohydrate)

Cat. No.: HY-14546A Purity: 99.83%
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Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19.

For research use only. We do not sell to patients.

CAS No. : 851220-85-4

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Based on 11 publication(s) in Google Scholar

Other Forms of Aripiprazole monohydrate:

Aripiprazole monohydrate Related Antibodies

Top Publications Citing Use of Products

    Aripiprazole monohydrate purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739.  [Abstract]

    We evaluated the therapeutic effects of Aripiprazole (1 mg/kg, ip, single dose) on the electrophysiological activities of MK‐801‐treated mice.

    Aripiprazole monohydrate purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739.  [Abstract]

    In the MK-801 group, theta power was significantly reduced by Aripiprazole (1 mg/kg, ip, single dose) treatment.

    Aripiprazole monohydrate purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739.  [Abstract]

    The spontaneous spike activity of RS and FS units were significantly reduced by Aripiprazole (1 mg/kg, ip, single dose) treatment in the MK-801 group.

    Aripiprazole monohydrate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Jan 14;25(2):1035.

    Histogram showing the average percentage of change from the vehicle/vehicle-treated group for the PLF of the gamma-band ASSR recorded in rats' global cortex following an acute administration with Aripiprazole (0 and 3 mg/kg) and MK-801 in comparison with vehicle/vehicle-treated animals and MK-801/vehicle-treated animals.

    Aripiprazole monohydrate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Jan 14;25(2):1035.

    Horizontal activity plotted over 240 min following an acute administration with Aripiprazole (Ari) at 1, 3, 10 and 30 mg/kg in MK-801-treated rats in comparison with vehicle (Veh)/vehicle-treated, MK-801/vehicle-treated or MK-801/clozapine (Cloza)-treated rats (clozapine being used as a positive control).

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    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19[1][2][3][4].

    IC50 & Target

    5-HT1A Receptor

     

    5-HT2A Receptor

     

    5-HT2B Receptor

     

    5-HT2C Receptor

     

    D2 Receptor

     

    D3 Receptor

     

    D4 Receptor

     

    In Vitro

    Aripiprazole monohydrate potently activates D2 receptor-mediated inhibition of cAMP accumulation[1].
    Aripiprazole monohydrate shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Aripiprazole monohydrate Related Antibodies
    In Vivo

    Aripiprazole monohydrate (0-3 mg/kg, IP, daily) shows some anxiolytic properties[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)[4]
    Dosage: 0, 0.3, 1, 3 mg/kg
    Administration: IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments
    Result: Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
    Clinical Trial
    Molecular Weight

    466.40

    Formula

    C23H29Cl2N3O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1NC2=C(C=CC(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CC1.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Purity & Documentation
    References
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    Aripiprazole monohydrate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aripiprazole851220-85-4OPC-14597OPC14597OPC 145975-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorCHO-D2L cellsAntipsychoticDopamineSerotoninPrefrontal cortexHippocampusCOVID19Inhibitorinhibitorinhibit

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