2. Others GPCR/G Protein Neuronal Signaling
  3. Isotope-Labeled Compounds 5-HT Receptor
  4. Aripiprazole-d8

Aripiprazole-d8  (Synonyms: OPC-14597-d8)

製品番号: HY-14546S1 純度: 99.86%
COA 取扱説明書 Technical Support

Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

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CAS 番号 : 1089115-04-7

容量 価格（税別） 在庫状況 数量
500 μg $190 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
1 mg $310 在庫あり
5 mg   お問い合わせ  
10 mg   お問い合わせ  

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カスタマーレビュー

Based on 11 publication(s) in Google Scholar

Other Forms of Aripiprazole-d8:

Aripiprazole-d8 関連抗体

Top Publications Citing Use of Products

    Aripiprazole-d8 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739.  [Abstract]

    We evaluated the therapeutic effects of Aripiprazole (1 mg/kg, ip, single dose) on the electrophysiological activities of MK‐801‐treated mice.

    Aripiprazole-d8 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739.  [Abstract]

    In the MK-801 group, theta power was significantly reduced by Aripiprazole (1 mg/kg, ip, single dose) treatment.

    Aripiprazole-d8 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739.  [Abstract]

    The spontaneous spike activity of RS and FS units were significantly reduced by Aripiprazole (1 mg/kg, ip, single dose) treatment in the MK-801 group.

    Aripiprazole-d8 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Jan 14;25(2):1035.  [Abstract]

    Histogram showing the average percentage of change from the vehicle/vehicle-treated group for the PLF of the gamma-band ASSR recorded in rats' global cortex following an acute administration with Aripiprazole (0 and 3 mg/kg) and MK-801 in comparison with vehicle/vehicle-treated animals and MK-801/vehicle-treated animals.

    Aripiprazole-d8 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Jan 14;25(2):1035.  [Abstract]

    Horizontal activity plotted over 240 min following an acute administration with Aripiprazole (Ari) at 1, 3, 10 and 30 mg/kg in MK-801-treated rats in comparison with vehicle (Veh)/vehicle-treated, MK-801/vehicle-treated or MK-801/clozapine (Cloza)-treated rats (clozapine being used as a positive control).

    5-HT Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2].

    Application

    1. This compound can be used as a tracer.
    2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

    IC50 & Target

    5-HT1A Receptor

     

    体外実験

    Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Aripiprazole-d8 関連抗体
    分子量

    456.43

    分子式

    C23H19D8Cl2N3O2
    CAS 番号
    Unlabeled CAS
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1NC2=C(C=CC(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CC1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMF : ≥ 30 mg/mL (65.73 mM)

    DMSO : ≥ 25 mg/mL (54.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : ≥ 1 mg/mL (2.19 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1909 mL 10.9546 mL 21.9092 mL
    5 mM 0.4382 mL 2.1909 mL 4.3818 mL
    10 mM 0.2191 mL 1.0955 mL 2.1909 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO / DMF 1 mM 2.1909 mL 10.9546 mL 21.9092 mL 54.7729 mL
    DMSO / DMF 5 mM 0.4382 mL 2.1909 mL 4.3818 mL 10.9546 mL
    10 mM 0.2191 mL 1.0955 mL 2.1909 mL 5.4773 mL
    15 mM 0.1461 mL 0.7303 mL 1.4606 mL 3.6515 mL
    20 mM 0.1095 mL 0.5477 mL 1.0955 mL 2.7386 mL
    25 mM 0.0876 mL 0.4382 mL 0.8764 mL 2.1909 mL
    30 mM 0.0730 mL 0.3652 mL 0.7303 mL 1.8258 mL
    40 mM 0.0548 mL 0.2739 mL 0.5477 mL 1.3693 mL
    50 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0955 mL
    DMF 60 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.9129 mL
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    Aripiprazole-d8 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aripiprazole-d81089115-04-7OPC-14597-d8Isotope-Labeled Compounds5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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    製品名:
    Aripiprazole-d8
    製品番号:
    HY-14546S1
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