Aripiprazole-d₈ (Synonyms: OPC-14597-d₈)

Name: Aripiprazole-d 8
Brand: MedChemExpress
SKU: HY-14546S1
Rating: 5.0 (11 reviews)

Cat. No.: HY-14546S1 Purity: 99.86%: Data Sheet
COA

SDS
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Aripiprazole (1,1,2,2,3,3,4,4-d₈) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a K_i of 4.2 nM.

For research use only. We do not sell to patients.

CAS No. : 1089115-04-7

Size	Stock	Quantity
500 μg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Aripiprazole-d₈:

Aripiprazole In-stock

11 Publications Citing Use of MCE Aripiprazole-d₈

In Vivo Efficacy Study

: Aripiprazole-d₈ purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739. [Abstract]; We evaluated the therapeutic effects of Aripiprazole (1 mg/kg, ip, single dose) on the electrophysiological activities of MK‐801‐treated mice.

: Aripiprazole-d₈ purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739. [Abstract]; In the MK-801 group, theta power was significantly reduced by Aripiprazole (1 mg/kg, ip, single dose) treatment.

: Aripiprazole-d₈ purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 May;30(5):e14739. [Abstract]; The spontaneous spike activity of RS and FS units were significantly reduced by Aripiprazole (1 mg/kg, ip, single dose) treatment in the MK-801 group.

: Aripiprazole-d₈ purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Jan 14;25(2):1035.; Histogram showing the average percentage of change from the vehicle/vehicle-treated group for the PLF of the gamma-band ASSR recorded in rats' global cortex following an acute administration with Aripiprazole (0 and 3 mg/kg) and MK-801 in comparison with vehicle/vehicle-treated animals and MK-801/vehicle-treated animals.

: Aripiprazole-d₈ purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Jan 14;25(2):1035.; Horizontal activity plotted over 240 min following an acute administration with Aripiprazole (Ari) at 1, 3, 10 and 30 mg/kg in MK-801-treated rats in comparison with vehicle (Veh)/vehicle-treated, MK-801/vehicle-treated or MK-801/clozapine (Cloza)-treated rats (clozapine being used as a positive control).

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Purity & Documentation
References
Customer Review

Description

Aripiprazole (1,1,2,2,3,3,4,4-d₈) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a K_i of 4.2 nM^[1]^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC₅₀ & Target

5-HT_1A Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

456.43

Formula

C₂₃H₁₉D₈Cl₂N₃O₂

CAS No.

1089115-04-7

Unlabeled CAS

129722-12-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C=CC(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 30 mg/mL (65.73 mM)

DMSO : ≥ 25 mg/mL (54.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 1 mg/mL (2.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1909 mL	10.9546 mL	21.9092 mL
5 mM	0.4382 mL	2.1909 mL	4.3818 mL
10 mM	0.2191 mL	1.0955 mL	2.1909 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (273 KB) SDS (254 KB)

COA (247 KB) HNMR (1569 KB) RP-HPLC (1718 KB) MS (1629 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20. [Content Brief]

[3]. Burris KD, Molski TF, Xu C et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9. [Content Brief]

[4]. Swainston Harrison T, Perry CM. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36. [Content Brief]

[5]. Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T. Nagasaka Y, Oda K, Iwatsubo T, Kawamura A, Usui T. Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier. Biopharm Drug Dispos. 2012 Jul 27. doi: 10.1002/bdd.1801. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO / DMF	1 mM	2.1909 mL	10.9546 mL	21.9092 mL	54.7729 mL
DMSO / DMF	5 mM	0.4382 mL	2.1909 mL	4.3818 mL	10.9546 mL
	10 mM	0.2191 mL	1.0955 mL	2.1909 mL	5.4773 mL
	15 mM	0.1461 mL	0.7303 mL	1.4606 mL	3.6515 mL
	20 mM	0.1095 mL	0.5477 mL	1.0955 mL	2.7386 mL
	25 mM	0.0876 mL	0.4382 mL	0.8764 mL	2.1909 mL
	30 mM	0.0730 mL	0.3652 mL	0.7303 mL	1.8258 mL
	40 mM	0.0548 mL	0.2739 mL	0.5477 mL	1.3693 mL
	50 mM	0.0438 mL	0.2191 mL	0.4382 mL	1.0955 mL
DMF	60 mM	0.0365 mL	0.1826 mL	0.3652 mL	0.9129 mL

Aripiprazole-d₈ Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aripiprazole-d₈1089115-04-7OPC-14597-d₈Isotope-Labeled Compounds5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Aripiprazole-d8 (Synonyms: OPC-14597-d8)

Customer Review

Other Forms of Aripiprazole-d8:

Aripiprazole-d8 Related Antibodies

11 Publications Citing Use of MCE Aripiprazole-d8

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References

Customer Review

Aripiprazole-d8 Related Antibodies

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Complete Stock Solution Preparation Table

Aripiprazole-d8 Related Classifications

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Aripiprazole-d₈ (Synonyms: OPC-14597-d₈)

Other Forms of Aripiprazole-d₈:

Aripiprazole-d₈ Related Antibodies

11 Publications Citing Use of MCE Aripiprazole-d₈

Aripiprazole-d₈ Related Antibodies

Aripiprazole-d₈ Related Classifications