2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Adenylosuccinic acid tetraammonium

Adenylosuccinic acid tetraammonium  (Synonyms: Adenylosuccinate tetraammonium; Aspartyl adenylate tetraammonium)

Cat. No.: HY-127137A Purity: ≥98.0%
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Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is an orally active purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD).

For research use only. We do not sell to patients.

Adenylosuccinic acid tetraammonium Chemical Structure

Adenylosuccinic acid tetraammonium Chemical Structure

Size Price Stock Quantity
5 mg USD 562 In-stock
10 mg USD 900 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Adenylosuccinic acid tetraammonium:

Adenylosuccinic acid tetraammonium Related Antibodies

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Description

Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is an orally active purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD)[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Adenylosuccinic acid tetraammonium (oral administration; 3-3000 µg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca2+ content of mdx tibialis anterior[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/10ScSn (normal wild-type strain; Con) and C57Bl/10mdx (mdx) mice[1]
Dosage: 3 µg/mL, 30 µg/mL, 300 µg/mL, 3000 µg/mL
Administration: 3 µg/mL for 3 days and 30 µg/mL for the next 4 days, and 300 µg/mL for one week, and then 3000 µg/mL for 6 weeks
Result: Ameliorated the symptoms of murine duchenne muscular dystrophy.
Molecular Weight

531.42

Formula

C14H30N9O11P
Appearance

Solid

Color

White to off-white

SMILES

O=C(C[C@H](NC1=C2N=CN(C2=NC=N1)[C@H]3[C@H](O)[C@H](O)[C@H](O3)COP(O)(O)=O)C(O)=O)O.N.N.N.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 200 mg/mL (376.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8818 mL 9.4088 mL 18.8175 mL
5 mM 0.3764 mL 1.8818 mL 3.7635 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8818 mL 9.4088 mL 18.8175 mL 47.0438 mL
5 mM 0.3764 mL 1.8818 mL 3.7635 mL 9.4088 mL
10 mM 0.1882 mL 0.9409 mL 1.8818 mL 4.7044 mL
15 mM 0.1255 mL 0.6273 mL 1.2545 mL 3.1363 mL
20 mM 0.0941 mL 0.4704 mL 0.9409 mL 2.3522 mL
25 mM 0.0753 mL 0.3764 mL 0.7527 mL 1.8818 mL
30 mM 0.0627 mL 0.3136 mL 0.6273 mL 1.5681 mL
40 mM 0.0470 mL 0.2352 mL 0.4704 mL 1.1761 mL
50 mM 0.0376 mL 0.1882 mL 0.3764 mL 0.9409 mL
60 mM 0.0314 mL 0.1568 mL 0.3136 mL 0.7841 mL
80 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5880 mL
100 mM 0.0188 mL 0.0941 mL 0.1882 mL 0.4704 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Adenylosuccinic acid tetraammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenylosuccinic acid tetraammoniumAdenylosuccinate tetraammoniumAspartyl adenylate tetraammoniumEndogenous MetaboliteDuchennemusculardystrophyDMDmetabolitenucleotidecycleInhibitorinhibitorinhibit

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