1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Adenylosuccinic acid

Adenylosuccinic acid (Synonyms: Adenylosuccinate; Aspartyl adenylate)

Cat. No.: HY-127137
Handling Instructions

Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD).

For research use only. We do not sell to patients.

Adenylosuccinic acid Chemical Structure

Adenylosuccinic acid Chemical Structure

CAS No. : 19046-78-7

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Description

Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1].

IC50 & Target

IC50: ribonucleoside monophosphate[1]

In Vivo

Adenylosuccinic acid (oral administration; 3-3000 µg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca2+ content of mdx tibialis anterior[1].

Animal Model: C57Bl/10ScSn (normal wild-type strain; Con) and C57Bl/10mdx (mdx) mice[1]
Dosage: 3 µg/mL, 30 µg/mL, 300 µg/mL, 3000 µg/mL
Administration: 3 µg/mL for 3 days and 30 µg/mL for the next 4 days, and 300 µg/mL for one week, and then 3000 µg/mL for 6 weeks
Result: Ameliorated the symptoms of murine duchenne muscular dystrophy.
Molecular Weight

463.29

Formula

C₁₄H₁₈N₅O₁₁P

CAS No.

19046-78-7

SMILES

O=C(C[[email protected]](NC1=C2N=CN(C2=NC=N1)[[email protected]]3[[email protected]](O)[[email protected]](O)[[email protected]](O3)COP(O)(O)=O)C(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Adenylosuccinic acidAdenylosuccinateAspartyl adenylateEndogenous MetaboliteDuchennemusculardystrophyDMD metabolite nucleotidecycleInhibitorinhibitorinhibit

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Adenylosuccinic acid
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