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Adenosine 5′-diphosphoribose

(Synonyms: ADP ribose)
9 Cited Publications
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Based on 9 publication(s) in Google Scholar

Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy.

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  • Purity: 98.21%
  • CAS No.: 20762-30-5
  • Formula: C15H23N5O14P2
  • Molecular Weight:559.32
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Adenosine 5′-diphosphoribose Chemical Structure
    Adenosine 5′-diphosphoribose Chemical Structure
  • Experimental Validation Results for Adenosine 5′-diphosphoribose
  • Experimental Validation Results for Adenosine 5′-diphosphoribose
  • Experimental Validation Results for Adenosine 5′-diphosphoribose
CAS No.: 20762-30-5
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  • Adenosine 5′-diphosphoribose Chemical Structure
    Adenosine 5′-diphosphoribose Chemical Structure
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    Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]

    Customer Validation
     Results indicated that a minimum concentration of 5 μM was sufficient to enhance sensitivity and improve peak shape for the analytes. The sensitivity was enhanced by about 12-fold for cADPR, 40-fold for NMN, 5-fold for NAD, and 3-fold for ADPR. Analysis was performed on a mixed sample of 2ng/mL cADPR, 0.2 ng/mL NMN, 20 ng/mL NAD, and 20 ng/mL ADPR (Adenosine 5′-diphosphoribose sodium) using the Water Atlantis Premier BEH C18 AX column.

  • 1/16

    Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]

    Customer Validation
     MRM chromatograms showing NAD+, NMN, NAM, ADPR (Adenosine 5′-diphosphoribose sodium), cADPR, and IS peaks detected using LC-MS/MS.

  • 1/16

    Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]

    Customer Validation
     Compared to the normal nerve, a decreased NAD+ level and increased NMN level in the injured nerves were observed, resulting in about a 2-fold increase in NMN/NAD+ ratio. The level of NAM and ADPR (Adenosine 5′-diphosphoribose sodium) decreased by about 2-fold, and cADPR increased by more than 8-fold.

  • Adenosine 5′-diphosphoribose