Adenosine 5′-diphosphoribose (Synonyms: ADP ribose)

Name: Adenosine 5′-diphosphoribose
Brand: MedChemExpress
SKU: HY-100973
Rating: 5.0 (8 reviews)

Cat. No.: HY-100973 Purity: 98.21%: Data Sheet
COA

SDS
Handling Instructions
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Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD⁺) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy.

For research use only. We do not sell to patients.

CAS No. : 20762-30-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Adenosine 5′-diphosphoribose:

Adenosine 5′-diphosphoribose sodium In-stock
Adenosine 5′-diphosphoribose (Standard) Get quote

8 Publications Citing Use of MCE Adenosine 5′-diphosphoribose

Bio/Physico-chemical Assay

RT-PCR

: Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]; Results indicated that a minimum concentration of 5 μM was sufficient to enhance sensitivity and improve peak shape for the analytes. The sensitivity was enhanced by about 12-fold for cADPR, 40-fold for NMN, 5-fold for NAD, and 3-fold for ADPR. Analysis was performed on a mixed sample of 2ng/mL cADPR, 0.2 ng/mL NMN, 20 ng/mL NAD, and 20 ng/mL ADPR (Adenosine 5′-diphosphoribose sodium) using the Water Atlantis Premier BEH C18 AX column.

: Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]; MRM chromatograms showing NAD+, NMN, NAM, ADPR (Adenosine 5′-diphosphoribose sodium), cADPR, and IS peaks detected using LC-MS/MS.

: Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]; Compared to the normal nerve, a decreased NAD+ level and increased NMN level in the injured nerves were observed, resulting in about a 2-fold increase in NMN/NAD+ ratio. The level of NAM and ADPR (Adenosine 5′-diphosphoribose sodium) decreased by about 2-fold, and cADPR increased by more than 8-fold.

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View All TRP Channel Isoform Specific Products:

View All Isoforms

TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

In mouse embryonic fibroblasts (MEFs), H₂O₂ treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca²⁺ elevation through extracellular Ca²⁺ influx and (or) lysosomal Ca²⁺ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress^[1]^[1].
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca²⁺ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

559.32

Formula

C₁₅H₂₃N₅O₁₄P₂

CAS No.

20762-30-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@H]([C@H]([C@H](C=O)O)O)O)(O)=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (312.88 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7879 mL	8.9394 mL	17.8789 mL
5 mM	0.3576 mL	1.7879 mL	3.5758 mL
10 mM	0.1788 mL	0.8939 mL	1.7879 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.21%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (250 KB) HNMR (282 KB) CNMR (291 KB) RP-HPLC (277 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62. [Content Brief]

[2]. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7879 mL	8.9394 mL	17.8789 mL	44.6971 mL
	5 mM	0.3576 mL	1.7879 mL	3.5758 mL	8.9394 mL
	10 mM	0.1788 mL	0.8939 mL	1.7879 mL	4.4697 mL
	15 mM	0.1192 mL	0.5960 mL	1.1919 mL	2.9798 mL
	20 mM	0.0894 mL	0.4470 mL	0.8939 mL	2.2349 mL
	25 mM	0.0715 mL	0.3576 mL	0.7152 mL	1.7879 mL
	30 mM	0.0596 mL	0.2980 mL	0.5960 mL	1.4899 mL
	40 mM	0.0447 mL	0.2235 mL	0.4470 mL	1.1174 mL
	50 mM	0.0358 mL	0.1788 mL	0.3576 mL	0.8939 mL
	60 mM	0.0298 mL	0.1490 mL	0.2980 mL	0.7450 mL
	80 mM	0.0223 mL	0.1117 mL	0.2235 mL	0.5587 mL
	100 mM	0.0179 mL	0.0894 mL	0.1788 mL	0.4470 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Adenosine 5′-diphosphoribose Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine 5′-diphosphoribose20762-30-5ADP riboseTRP ChannelAutophagyTransient receptor potential channelsTRPM2Ca2+NAD+metabolitePARP-1autophagysodiumintracellularInhibitorinhibitorinhibit

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Adenosine 5′-diphosphoribose (Synonyms: ADP ribose)

Customer Review

Other Forms of Adenosine 5′-diphosphoribose:

Adenosine 5′-diphosphoribose Related Antibodies

8 Publications Citing Use of MCE Adenosine 5′-diphosphoribose

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All TRP Channel Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Adenosine 5′-diphosphoribose Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Adenosine 5′-diphosphoribose Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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