Adenosine 5′-diphosphoribose
Based on 9 publication(s) in Google Scholar
Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy.
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- Pureté: 98.21%
- CAS No.: 20762-30-5
- Formule: C15H23N5O14P2
- Masse moléculaire:559.32
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Adenosine 5′-diphosphoribose
More- Signal Transduct Target Ther. 2026 Mar 26;11(1):113. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mol Cell. 2023 Dec 21;83(24):4600-4613.e6. [Abstract]
- Cell Rep Med. 2024 Feb 20;5(2):101400. [Abstract]
- Chem Eng J. 2026 Feb 5.
- Int J Biol Macromol. 2026 May 6:152409. [Abstract]
- EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
- J Chromatogr A. 2024 Apr 26:1721:464821. [Abstract]
- Res Sq. 2026 Mar 5.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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RT-PCR
Activité biologique
In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1].
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 20762-30-5
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Appearance Solid
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Masse moléculaire 559.32
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Formule C15H23N5O14P2
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Color Light yellow to yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@H]([C@H]([C@H](C=O)O)O)O)(O)=O)(O)=O
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Synonyms
ADP ribose
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (9)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer. [Abstract]2026 Mar 26;11(1):113. PMID: 41888107 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mol Cell
2023 Dec 21;83(24):4600-4613.e6. PMID: 38096825 -
Cell Rep Med
Inhibition of CD38 enzymatic activity enhances CAR-T cell immune-therapeutic efficacy by repressing glycolytic metabolism. [Abstract]2024 Feb 20;5(2):101400. PMID: 38307031 -
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Int J Biol Macromol
Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation. [Abstract]2026 May 6:152409. PMID: 42103119 -
EMBO J
Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat. [Abstract]2025 Aug;44(15):4222-4251. PMID: 40537608
Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
Results indicated that a minimum concentration of 5 μM was sufficient to enhance sensitivity and improve peak shape for the analytes. The sensitivity was enhanced by about 12-fold for cADPR, 40-fold for NMN, 5-fold for NAD, and 3-fold for ADPR. Analysis was performed on a mixed sample of 2ng/mL cADPR, 0.2 ng/mL NMN, 20 ng/mL NAD, and 20 ng/mL ADPR (Adenosine 5′-diphosphoribose sodium) using the Water Atlantis Premier BEH C18 AX column.
Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
MRM chromatograms showing NAD+, NMN, NAM, ADPR (Adenosine 5′-diphosphoribose sodium), cADPR, and IS peaks detected using LC-MS/MS.
Adenosine 5′-diphosphoribose purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Aug;44(15):4222-4251. [Abstract]
Compared to the normal nerve, a decreased NAD+ level and increased NMN level in the injured nerves were observed, resulting in about a 2-fold increase in NMN/NAD+ ratio. The level of NAM and ADPR (Adenosine 5′-diphosphoribose sodium) decreased by about 2-fold, and cADPR increased by more than 8-fold.
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J Chromatogr A
Development and validation of an LC-MS/MS method for quantifying NAD+ and related metabolites in mice sciatic nerves and its application to a nerve injury animal model. [Abstract]2024 Apr 26:1721:464821. PMID: 38547681 -
Solvant et solubilité
H2O : 175 mg/mL (312.88 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62. [Content Brief]
[2]. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7879 mL | 8.9394 mL | 17.8789 mL | 44.6971 mL |
| 5 mM | 0.3576 mL | 1.7879 mL | 3.5758 mL | 8.9394 mL | |
| 10 mM | 0.1788 mL | 0.8939 mL | 1.7879 mL | 4.4697 mL | |
| 15 mM | 0.1192 mL | 0.5960 mL | 1.1919 mL | 2.9798 mL | |
| 20 mM | 0.0894 mL | 0.4470 mL | 0.8939 mL | 2.2349 mL | |
| 25 mM | 0.0715 mL | 0.3576 mL | 0.7152 mL | 1.7879 mL | |
| 30 mM | 0.0596 mL | 0.2980 mL | 0.5960 mL | 1.4899 mL | |
| 40 mM | 0.0447 mL | 0.2235 mL | 0.4470 mL | 1.1174 mL | |
| 50 mM | 0.0358 mL | 0.1788 mL | 0.3576 mL | 0.8939 mL | |
| 60 mM | 0.0298 mL | 0.1490 mL | 0.2980 mL | 0.7450 mL | |
| 80 mM | 0.0223 mL | 0.1117 mL | 0.2235 mL | 0.5587 mL | |
| 100 mM | 0.0179 mL | 0.0894 mL | 0.1788 mL | 0.4470 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Adenosine 5′-diphosphoribose Related Classifications
HY-100973 Related Classifications
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