20762-30-5
20762-30-5
Chemical Structure
Adenosine 5′-diphosphoribose
Synonym(s): ADP ribose
- CAS No.: 20762-30-5
- Formula:C15H23N5O14P2
- Molecular Weight:559.32
InChIKey: PWJFNRJRHXWEPT-AOOZFPJJSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@H]([C@H]([C@H](C=O)O)O)O)(O)=O)(O)=O
Biological Activity: Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy[1][2].
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Adenosine 5′-diphosphoribose | 98.21% | Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy. | ||||||||||||||||||||
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Adenosine 5′-diphosphoribose (Standard) | ≥98% | Adenosine 5′-diphosphoribose (Standard) (ADP ribose (Standard)) is the analytical standard of Adenosine 5′-diphosphoribose (HY-100973). This product is intended for research and analytical applications. Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.92
HY-100973ARAdenosine 5′-diphosphoribose sodium (Standard) -
Similarity Score 0.81
HY-134031Ara-ATP -
Similarity Score 0.81
HY-B2176RATP (Standard) -
Similarity Score 0.80
HY-150709SATP-13C10,15N5 ammonium solution (100mM) -
Similarity Score 0.80
HY-B2176EATP magnesium -
Similarity Score 0.80
HY-B2176CATP dipotassium -
Similarity Score 0.80
HY-W010918Adenosine 5'-diphosphate -
Similarity Score 0.79
HY-180696Adenosine tetraphosphate -
Similarity Score 0.78
HY-157906ADP-β-D-ribofuranose -
Explore the MedChemAI to find more analogs
References
- [1]. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62. [Content Brief]
- [2]. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5. [Content Brief]
